The PopLife browser – a population genomics resource
We have developed PopLife (https://poplife.pic.es), a high-performance pipeline designed for the analysis and visualization of genomic variation and the inference of adaptation across populations of any species.
Our next challenge is to expand the capabilities of PopLife both in terms of data integration, visualization interface and analytical power, paving the way for new discoveries in evolutionary biology and structural genomics.
Comparative adaptation across genes and species
Adaptation results from a complex interaction between genetic factors and selective pressures imposed by ecological and geographic contexts.
Our research examines how these variables shape genomic adaptation, identifying both shared and species-specific adaptive features. We leverage the analytical capabilities of PopLife to explore the relationship between genetic variation and environmental factors.
Genomic variation, recombination and adaptation in 3D
Advances in population genomics and 3D genome structure research have rarely been integrated. With PopLife, we aim to bridge this gap by exploring the interaction between 3D chromosome organization, genetic variation, recombination, and adaptation.
We will integrate chromatin conformation data (e.g., Hi-C) and recombination maps with population genomic analyses to identify how the spatial organization of the genome influences the distribution and regulation of adaptive genetic variants.