Research Lines
Identification of Novel Biomarkers for Male Infertility
Male infertility remains unexplained in a significant proportion of patients, highlighting the need for more accurate diagnostic tools. At GMF, we investigate the genetic, genomic and cellular factors underlying male reproductive dysfunction to identify biomarkers associated with impaired spermatogenesis, sperm dysfunction and reproductive outcomes. By integrating molecular, cytogenetic and genomic approaches, our research aims to improve the diagnosis and prognosis of male infertility and support the development of precision reproductive medicine.
Chromosome territoriality in spermatogenic cells
The spatial organization of chromosomes is essential for genome function and stability. At GMF, we investigate how chromosome territoriality, homologous chromosome interactions and three-dimensional genome architecture are established during spermatogenesis, and how these processes influence meiosis, genome stability and male fertility. By combining cytogenetic, molecular and imaging approaches, our research aims to uncover the mechanisms governing chromosome organization in germ cells and their implications for reproductive health and chromosome abnormalities.
Emerging Threats to Reproductive Health
Environmental and lifestyle factors are increasingly recognized as important modulators of reproductive health. At GMF, we investigate how diet, the seminal microbiome, and emerging environmental contaminants such as nanoplastics influence male fertility, with a particular focus on sperm quality, reproductive function, and genomic integrity. By integrating cellular, molecular, and genomic approaches, our research aims to uncover the mechanisms underlying environmentally mediated reproductive dysfunction and to assess their potential impact on human fertility and offspring health.