{"id":16,"date":"2023-07-26T12:36:55","date_gmt":"2023-07-26T10:36:55","guid":{"rendered":"https:\/\/webs.uab.cat\/innovative-biodrugs\/?page_id=16"},"modified":"2023-09-29T09:17:08","modified_gmt":"2023-09-29T07:17:08","slug":"publications","status":"publish","type":"page","link":"https:\/\/webs.uab.cat\/innovative-biodrugs\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Elisa Rioja-Blanco; Irene Arroyo-Solera; Patricia \u00c1lamo; Isolda Casanova; Alberto Gallardo; Ugutz Unzueta; Naroa Serna; Laura S\u00e1nchez-Garc\u00eda; Miquel Quer; Antonio Villaverde; Esther V\u00e1zquez; Ramon Mangues; Lorena Alba-Castell\u00f3n; Xavier Le\u00f3n. 2022. Self-assembling protein nanocarrier for the selective delivery of cytotoxic polypeptides to CXCR4+ head and neck squamous cell carcinoma tumors. Acta Pharmaceutica Sinica B, 12: 2578-2591. IF: 14.5 Lugar que ocupa en PHARMACOLOGY &amp; PHARMACY: 5\/277 (Q1, D1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">H\u00e8ctor L\u00f3pez-Laguna, Eric Volt\u00e0-Dur\u00e1n, Eloi Parlad\u00e9, Antonio Villaverde, Esther V\u00e1zquez, Ugutz Unzueta. 2022. Insights on the emerging biotechnology of histidine-rich peptides. Biotechnology Advances. 54, 107817. IF: 16 Lugar que ocupa en BIOTECHNOLOGY &amp; APPLIED MICROBIOLOGY: 4\/156 (Q1, D1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Victor Pallar\u00e8s, Ugutz Unzueta, A\u00efda Falg\u00e0s, Anna Avi\u00f1\u00f3, Y\u00e1iza N\u00fa\u00f1ez, Annabel Garc\u00eda-Le\u00f3n, Laura S\u00e1nchez-Garc\u00eda, Naroa Serna, Alberto Gallardo, Lorena Alba-Castell\u00f3n, Patricia \u00c1lamo, Jorge Sierra, L\u00eddia Ced\u00f3, Ram\u00f3n Eritja, Antonio Villaverde, Esther V\u00e1zquez, Isolda Casanova, Ramon Mangues. 2022. A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model. Biomaterials 280, 121258. IF: 12.4. Lugar que ocupa en MATERIALS SCIENCE, BIOMATERIALS: 2\/45 (Q1, D1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Eric Volt\u00e0-Dur\u00e1n, Julieta M\u00aa S\u00e1nchez, H\u00e8ctor-L\u00f3pez-Laguna, Eloi Parlad\u00e9, Laura S\u00e1nchez-Garc\u00eda, Alejandro S\u00e1nchez-Chardi, Ario de Marco, Ugutz Unzueta, Esther V\u00e1zquez and Antonio Villaverde. 2022. The spectrum of building block conformers sustain the biophysical properties of clinically-oriented, self-assembling protein nanoparticles. SCIENCE CHINA Materials 65: 1662-1670. IF: 14.227. Lugar que ocupa en BIOTECHNOLOGY &amp; APPLIED MICROBIOLOGY: 4\/159 (Q1, D1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Naroa Serna, Victor Pallar\u00e8s, Ugutz Unzueta, Alejandro S\u00e1nchez-Chardi, Eric Volt\u00e0-Dur\u00e1n, Eloi Parlad\u00e9, Isolda Casanova, A\u00efda Falg\u00e0s, Lorena Alba-Castell\u00f3n, Jorge Sierra, Antonio Villaverde, Esther V\u00e1zquez and Ram\u00f3n Mangues. 2022. Engineering non-antibody human proteins as efficient scaffolds for selective, receptor-targeted drug delivery. Journal of Controlled Release, 343: 277-287. IF:10.8&nbsp;&nbsp; Lugar que ocupa en PHARMACOLOGY &amp; PHARMACY: 12\/277 (Q1, D1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Naroa Serna, A\u00efda Falg\u00e0s, Annabel Garc\u00eda-Le\u00f3n, Ugutz Unzueta, Y\u00e1iza N\u00fa\u00f1ez, Alejandro S\u00e1nchez-Chardi, Carlos Mart\u00ednez-Torr\u00f3, Ram\u00f3n Mangues, Esther Vazquez, Isolda Casanova, Antonio Villaverde. 2022. Time-prolonged release of tumor-targeted MMAE-protein nanoconjugates from implantable hybrid materials. Pharmaceutics, 14, 192. IF: 5.5 Lugar que ocupa en PHARMACOLOGY &amp; PHARMACY: 51\/277 (Q1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Elisa Rioja-Blanco, Irene Arroyo-Solera, Patricia \u00c1lamo, Isolda Casanova, Alberto Gallardo, Ugutz Unzueta, Naroa Serna, Laura S\u00e1nchez-Garc\u00eda, Miquel Quer, Antonio Villaverde, Esther V\u00e1zquez, Xavier Le\u00f3n, Lorena Alba-Castell\u00f3n &amp; Ramon Mangues. 2022. CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma. Journal of Experimental &amp; Clinical Cancer Research, 41: 49. IF: 11.3&nbsp; Lugar que ocupa en ONCOLOGY: 24\/241 (Q1, D1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Julieta Mar\u00eda S\u00e1nchez, Jos\u00e9 Vicente Carratal\u00e1, Naroa Serna, Ugutz Unzueta, Veronica Nolan, Alejandro S\u00e1nchez-Chardi, Eric Volt\u00e0-Dur\u00e1n, H\u00e8ctor L\u00f3pez-Laguna, Neus Ferrer-Miralles, Antonio Villaverde, Esther Vazquez. 2022. The poly-histidine tag H6 mediates structural and functional properties of disintegrating, protein-releasing inclusion bodies. Pharmaceutics. 14: 602. IF: 5.5 Lugar que ocupa en PHARMACOLOGY &amp; PHARMACY: 51\/277 (Q1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Irene Barguilla, Ugutz Unzueta, Jose Vicente Carratal\u00e1, Olivia Cano-Garrido, Antonio Villaverde, Alba Hern\u00e1ndez, Neus Ferrer-Miralles. 2022. Toxicity profiling of bacterial inclusion bodies in human Caco-2 cells. Frontiers in Bioengineering and Biotechnology 10, 842256. IF: 5.7 Lugar que ocupa en MULTIDISCIPLINARY SCIENCES: 16\/73 (Q1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">A\u00efda Falg\u00e0s, Annabel Garcia-Le\u00f3n, Y\u00e1iza N\u00fa\u00f1ez, Naroa Serna, Laura S\u00e1nchez-Garcia, Ugutz Unzueta, EricVolt\u00e0-Dur\u00e1n, Marc Arag\u00f3, Patricia \u00c1lamo, Lorena Alba-Castell\u00f3n, JorgeSierra, Alberto Gallardo, Antonio Villaverde, Esther V\u00e1zquez,&nbsp; Ramon Mangues, Isolda Casanova. 2022. A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4+ lymphoma cells without toxicity in immunocompromised and immunocompetent mice. Biomedicine &amp; Pharmacotherapy, 150: 112940. IF: ): 7.5&nbsp; Lugar que ocupa en PHARMACOLOGY &amp; PHARMACY: 23\/277&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (Q1, D1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Elisa Rioja-Blanco, Alberto Gallardo, Irene Arroyo-Solera, Patricia \u00c1lamo, Isolda Casanova, Ugutz Unzueta, Naroa Serna, Laura S\u00e1nchez-Garc\u00eda, Miquel Quer, Antonio Villaverde, Esther V\u00e1zquez, Xavier Le\u00f3n, Lorena Alba-Castell\u00f3n, Ramon Mangues. 2022. A novel CXCR4-targeted diphtheria toxin nanoparticle inhibits invasion and metastatic dissemination in a head and neck squamous cell carcinoma mouse model. Pharmaceutics, 14, 887. IF: 5.5 Lugar que ocupa en PHARMACOLOGY &amp; PHARMACY: 51\/277 (Q1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Rita Sala, Elisa Rioja-Blanco, Naroa Serna, Laura S\u00e1nchez-Garc\u00eda, Patricia \u00c1lamo, Lorena Alba-Castell\u00f3n, Isolda Casanova, Antonio L\u00f3pez-Pousa, Ugutz Unzueta, Mar\u00eda Virtudes C\u00e9spedes, Esther V\u00e1zquez, Antonio Villaverde &amp; Ramon Mangues. 2022. GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases. Drug Delivery, 29, 1384-1397. IF: 6&nbsp; Lugar que ocupa en PHARMACOLOGY &amp; PHARMACY: 37\/277&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (Q1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Eloi Parlad\u00e9, Eric Volt\u00e0-Dur\u00e1n, Olivia Cano-Garrido, Julieta M. S\u00e1nchez, Ugutz Unzueta, H\u00e8ctor L\u00f3pez-Laguna, Naroa Serna, Montserrat Cano, Manuel Rodr\u00edguez, Esther Vazquez, Antonio Villaverde. 2022. An in silico methodology that facilitates decision-making in the engineering of nanoscale protein materials. International Journal of Molecular Sciences, 23, 4958. IF: 5.6 Lugar que ocupa en BIOCHEMISTRY &amp; MOLECULAR BIOLOGY: 66\/285&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (Q1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Esperanza Medina-Guti\u00e9rrez, Mar\u00eda Virtudes C\u00e9spedes, Alberto Gallardo, Elisa Rioja-Blanco, Miquel \u00c0ngel Pav\u00f3n, Laura Asensio, Lourdes Farr\u00e9, Lorena Alba-Castell\u00f3n, Ugutz Unzueta, Antonio Villaverde, Esther V\u00e1zquez, Isolda Casanova, Ramon Mangues. 2022. Novel endometrial cancer models using sensitive metastasis tracing for CXCR4-targeted therapy in advanced disease. Biomedicines 10, 1680. IF: 4.7 Lugar que ocupa en PHARMACOLOGY &amp; PHARMACY: 69\/277&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (Q1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Marianna Teixeira de Pinho Favaro, Jan Atienza-Garriga, Carlos-Mart\u00ednez-Torr\u00f3, Eloi Parlad\u00e9, Esther V\u00e1zquez, Jos\u00e9 Luis Corchero, Neus Ferrer-Miralles, Antonio Villaverde. 2022. Recombinant vaccines in 2022: A perspective from the cell factory. Microbial Cell Factories, 21:203. IF: 6.4 Lugar que ocupa en BIOTECHNOLOGY &amp; APPLIED MICROBIOLOGY 20\/156&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (Q1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Olivia Cano-Garrido, Naroa Serna, Ugutz Unzueta, Eloi Parlad\u00e9, Ram\u00f3n Mangues, Antonio Villaverde, Esther V\u00e1zquez. 2022. Protein scaffolds in human clinics. Biotechnology Advances 61, 108032.&nbsp; IF: 16 Lugar que ocupa en BIOTECHNOLOGY &amp; APPLIED MICROBIOLOGY: 4\/156 (Q1, D1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Eric Volt\u00e0-Dur\u00e1n, Julieta M S\u00e1nchez, Eloi Parlad\u00e9, Naroa Serna, Esther V\u00e1zquez, Ugutz Unzueta, Antonio Villaverde. 2022. The diphtheria toxin translocation domain impairs receptor selectivity in cancer cell-targeted protein nanoparticles. Pharmaceutics, 14, 2644. IF: 5.5 Lugar que ocupa en PHARMACOLOGY &amp; PHARMACY: 51\/277 (Q1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Esperanza Medina-Guti\u00e9rrez, Annabel Garc\u00eda-Le\u00f3n, Alberto Gallardo, Patricia \u00c1lamo, Lorena Alba-Castell\u00f3n, Ugutz Unzueta, Antonio Villaverde, Esther Vazquez, Isolda Casanova, Ramon Mangues. 2022. Potent anticancer activity of CXCR4-targeted nanostructured toxins in aggressive endometrial cancer models. Cancers, 15; 85. IF: 5.2 Lugar que ocupa en ONCOLOGY: 72\/241&nbsp;&nbsp;&nbsp; (Q2)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Campo-P\u00e9rez V, Guallar-Garrido S, Luquin M, et al. 2022. The High Plasticity of Nonpathogenic Mycobacterium brumae Induces Rapid Changes in Its Lipid Profile during Pellicle Maturation: The Potential of This Bacterium as a Versatile Cell Factory for Lipid Compounds of Therapeutic Interest. Int J Mol Sci. 6; 23(21): 13609. (IF: 5.600 \/\/ Q1 \/\/ Biochemistry &amp; Molecular Biology)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Senserrich J, Guallar-Garrido S, Gomez-Mora E, et al. 2022. Remodeling the bladder tumor immune microenvironment by mycobacterial species with changes in their cell envelope composition. Front Immunol. 11; 13: 993401. (IF: 7.300 \/\/ Q1 \/\/ Immunology)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Guallar-Garrido S, Campo-P\u00e9rez V, P\u00e9rez-Trujillo M, et al. 2022. Mycobacterial surface characters remodeled by growth conditions drive different tumor-infiltrating cells and systemic IFN-\u03b3\/IL-17 release in bladder cancer treatment. Oncoimmunology. 11(1): 2051845. (IF: 7.200 \/\/ Q1 \/\/ Immunology)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Guallar-Garrido S, Almi\u00f1ana-Rap\u00fan F, Campo-P\u00e9rez V, et al. 2022. BCG Substrains Change Their Outermost Surface as a Function of Growth Media. Vaccines. 10(1): 40. (IF: 7.800 \/\/ Q1 \/\/ Immunology)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">G\u00f3mez AC, Lyons T, Mamat U, Yero D, Bravo M, Daura X, Elshafee O, Brunke S, Gahan CGM, O\u2019Driscoll M, Gibert I, O\u2019Sullivan TP. 2022. Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens. Eur J Med Chem. 242:114678. doi: 10.1016\/j.ejmech.2022.114678. (IF: 6.7 \/\/ Q1 \/\/ Chemistry Medicinal)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Yero D, Jia B, Gao F. 2022. Insights in Evolutionary and Genomic Microbiology: 2021. Editorial. Front Microbiol. 13:915593. doi: 10.3389\/fmicb.2022.915593. (IF: 5.2 \/\/ Q2 \/\/ Microbiology)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Gomes-Fernandes M, Gomez AC, Bravo M, Huedo P, Coves X, Prat-Aymerich C, Gibert I, Lacoma A, Yero D. 2022. Strain-specific interspecies interactions between co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization. Sci Rep. 12(1):3374. doi: 10.1038\/s41598-022-07018-5. (IF: 4.6 \/\/ Q2 \/\/ Multidicsiplinary)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">&nbsp;F Mart\u00edn, A Carre\u00f1o, R Mendoza, P Caruana, F Rodr\u00edguez, M Bravo, A Benito, N Ferrer-Miralles, M\u00aa V C\u00e9spedes, JL Corchero. All-in-one biofabrication and loading of recombinant vaults in human cells. 2022. Biofabrication 14(2). (IF=9.0; 11\/96 in Engineering, BiomedicalL. Q1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">F Rodr\u00edguez, P Caruana, N De la Fuente, P Espa\u00f1ol, M G\u00e1mez, J Balart, E Llurba, R Rovira, R Ruiz, C Mart\u00edn-Lorente, JL Corchero and M Virtudes C\u00e9spedes. Nano-Based Approved Pharmaceuticals for Cancer Treatment: Present and Future Challenges. 2022. Biomolecules 12(6): 784. (IF = 5.5; 70\/285 in Biochemistry &amp; Molecular Biology. Q1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">&nbsp;R Fern\u00e1ndez; A Carre\u00f1o; R Mendoza; A Benito; N Ferrer-Miralles; M\u00aa V C\u00e9spedes and JL Corchero. Escherichia coli as a new platform for the fast production of vault-like nanoparticles: an optimized protocol. 2022. International Journal of Molecular Sciences 23(24): 15543. (IF= 5.6; 66\/285 in Biochemistry &amp; Molecular Biology. Q1)<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Ferrer-Miralles N, Saccardo P, Corchero JL, Garcia-Fruit\u00f3s E. Recombinant Protein Production and Purification of Insoluble Proteins. Methods Mol Biol. 2022;2406:1-31. doi: 10.1007\/978-1-0716-1859-2_1.<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Barguilla I, Unzueta U, Carratal\u00e1 JV, Cano-Garrido O, Villaverde A, Hern\u00e1ndez A, Ferrer-Miralles N. Toxicity Profiling of Bacterial Inclusion Bodies in Human Caco-2 Cells. Front Bioeng Biotechnol. 2022 Apr 29;10:842256. doi: 10.3389\/fbioe.2022.842256. (IF: 5.7 \/\/ Q1 \/\/Multidisciplinary sciences).<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">S\u00e1nchez JM, Carratal\u00e1 JV, Gifre-Renom L, Ar\u00eds A, Garcia-Fruit\u00f3s E, Ferrer-Miralles N. Quality Control of Proteins Solubilized from Inclusion Bodies. Methods Mol Biol. 2022;2406:469-477. doi: 10.1007\/978-1-0716-1859-2_28.<\/p>\n\n\n\n<p class=\"has-gris-pubilla-background-color has-background has-small-font-size\">Ferrer-Miralles N, Saccardo P, Corchero JL, Garcia-Fruit\u00f3s E. Recombinant Protein Production and Purification of Insoluble Proteins. Methods Mol Biol. 2022;2406:1-31. doi: 10.1007\/978-1-0716-1859-2_1.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Elisa Rioja-Blanco; Irene Arroyo-Solera; Patricia \u00c1lamo; Isolda Casanova; Alberto Gallardo; Ugutz Unzueta; Naroa Serna; Laura S\u00e1nchez-Garc\u00eda; Miquel Quer; Antonio Villaverde; Esther V\u00e1zquez; Ramon Mangues; Lorena Alba-Castell\u00f3n; Xavier Le\u00f3n. 2022. Self-assembling protein nanocarrier for the selective delivery of cytotoxic polypeptides to CXCR4+ head and neck squamous cell carcinoma tumors. Acta Pharmaceutica Sinica B, 12: 2578-2591. 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