{"id":4159,"date":"2004-01-06T23:35:24","date_gmt":"2004-01-06T23:35:24","guid":{"rendered":"http:\/\/jordidomenechportfolio.wordpress.com\/?p=195"},"modified":"2004-01-06T23:35:24","modified_gmt":"2004-01-06T23:35:24","slug":"in-silico-in-vitro-in-vivo","status":"publish","type":"post","link":"https:\/\/webs.uab.cat\/jordidomenech\/2004\/01\/06\/in-silico-in-vitro-in-vivo\/","title":{"rendered":"In silico, in vitro, in vivo."},"content":{"rendered":"<p><em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=domenech%20metallothionein\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft  wp-image-196\" title=\"melanogaster\" src=\"https:\/\/webs.uab.cat\/jordidomenech\/wp-content\/uploads\/sites\/524\/2012\/01\/melanogaster.png\" alt=\"\" width=\"110\" height=\"110\" \/><\/a>Drosophila melanogaster<\/em> cont\u00e9 4 gens de MT funcionals, que semblen repartir-se la funcionalitat per el Cu i per el Zn, del que s&#8217;extreu dels nostres resultats in vitro. Aquests resultats in vitro, que ja havien predit estudis in silico, han estat confirmats amb estudis in vivo de resist\u00e8ncia a toxicitat per metalls de formes mutants de la mosca. Hem identificat senyals CD i Raman de participaci\u00f3 de ions clorur i sulfur, un fet in\u00e8dit en aquest tipus d&#8217;agregats. Tot plegat, en dos articles.<\/p>\n<ul>\n<li>\u00a0<em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12505162\" target=\"_blank\" rel=\"noopener\">MTO: the second member of a Drosophila dual copper-thionein system<\/a><\/em>. <strong>FEBS Letters<\/strong>. 2003 Jan 2;533(1-3):72-8. Domenech J, Palacios O, Villarreal L, Gonz\u00e1lez-Duarte P, Capdevila M, Atrian S.\u00a0<\/li>\n<li>\u00a0<em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16716195\" target=\"_blank\" rel=\"noopener\">The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification<\/a><\/em>. <strong>Genes to Cells<\/strong>. 2006 Jun;11(6):647-58. Egli D, Dom\u00e8nech J, Selvaraj A, Balamurugan K, Hua H, Capdevila M, Georgiev O, Schaffner W, Atrian S.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Drosophila melanogaster cont\u00e9 4 gens de MT funcionals, que semblen repartir-se la funcionalitat per el Cu i per el Zn, del que s&#8217;extreu dels nostres resultats in vitro. Aquests resultats in vitro, que ja havien predit estudis in silico, han estat confirmats amb estudis in vivo de resist\u00e8ncia a toxicitat per metalls de formes mutants [&hellip;]<\/p>\n","protected":false},"author":2840,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152],"tags":[181,184],"class_list":["post-4159","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-publicacions-recerca-cientifica","tag-tesi-doctoral"],"_links":{"self":[{"href":"https:\/\/webs.uab.cat\/jordidomenech\/wp-json\/wp\/v2\/posts\/4159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/webs.uab.cat\/jordidomenech\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/webs.uab.cat\/jordidomenech\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/webs.uab.cat\/jordidomenech\/wp-json\/wp\/v2\/users\/2840"}],"replies":[{"embeddable":true,"href":"https:\/\/webs.uab.cat\/jordidomenech\/wp-json\/wp\/v2\/comments?post=4159"}],"version-history":[{"count":0,"href":"https:\/\/webs.uab.cat\/jordidomenech\/wp-json\/wp\/v2\/posts\/4159\/revisions"}],"wp:attachment":[{"href":"https:\/\/webs.uab.cat\/jordidomenech\/wp-json\/wp\/v2\/media?parent=4159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/webs.uab.cat\/jordidomenech\/wp-json\/wp\/v2\/categories?post=4159"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/webs.uab.cat\/jordidomenech\/wp-json\/wp\/v2\/tags?post=4159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}