- Abstract
Acinetobacter baumannii, a worldwide emerging nosocomial pathogen, acquires antimicrobial resistances in response to DNA-damaging agents, which increase the expression of multiple error-prone DNA polymerase components. Here we show that the aminocoumarin novobiocin, which inhibits the DNA damage response in Gram-positive bacteria, also inhibits the expression of error-prone DNA polymerases in this Gram-negative multidrug-resistant pathogen and, consequently, its potential acquisition of antimicrobial resistance through DNA damage-induced mutagenesis.
- Alternate Journal
- Antimicrob. Agents Chemother.
- Authors
- Jara, Luis M, Barbé, Jordi, Aranda, Jesús, Bou, Germán, Cortés, Pilar, Arch, Marta, Corral, Jordi, and Pérez-Varela, María
- Citation Key
- 136
- COinS Data
- Date Published
- 2016 01
- DOI
- 10.1128/AAC.01810-15
- ISSN
- 1098-6596
- Issue
- 1
- Keywords
- Acinetobacter baumannii, Anti-Bacterial Agents, Bacterial Proteins, DNA Damage, DNA Repair, DNA-Directed DNA Polymerase, DNA, Bacterial, Drug Resistance, Bacterial, Gene Expression Regulation, Bacterial, Microbial Sensitivity Tests, Mutagenesis, Novobioci
- Pagination
- 637-9
- Journal
- Antimicrob Agents Chemother
- Volume
- 60
- Year of Publication
- 2016