- Abstract
The role of Acinetobacter baumannii ATCC 17978 UmuDC homologs A1S_0636-A1S_0637, A1S_1174-A1S_1173, and A1S_1389 (UmuDAb) in antibiotic resistance acquired through UV-induced mutagenesis was evaluated. Neither the growth rate nor the UV-related survival of any of the three mutants was significantly different from that of the wild-type parental strain. However, all mutants, and especially the umuDAb mutant, were less able to acquire resistance to rifampin and streptomycin through the activities of their error-prone DNA polymerases. Furthermore, in the A. baumannii mutant defective in the umuDAb gene, the spectrum of mutations included a dramatic reduction in the frequency of transition mutations, the mutagenic signature of the DNA polymerase V encoded by umuDC.
- Alternate Journal
- Antimicrob. Agents Chemother.
- Authors
- Aranda, Jesús, Barbé, Jordi, Bou, Germán, Adler, Ben, Magán, Andrés, Leiva, Enoy, and López, Mario
- Citation Key
- 141
- COinS Data
- Date Published
- 2014
- DOI
- 10.1128/AAC.02346-13
- ISSN
- 1098-6596
- Issue
- 3
- Keywords
- Acinetobacter baumannii, Anti-Bacterial Agents, DNA Damage, DNA-Directed DNA Polymerase, Drug Resistance, Bacterial, Mutagenesis, Rifampin, Streptomycin, Ultraviolet Rays
- Pagination
- 1771-3
- Journal
- Antimicrob Agents Chemother
- Volume
- 58
- Year of Publication
- 2014