{"id":561,"date":"2015-02-01T23:31:03","date_gmt":"2015-02-02T07:31:03","guid":{"rendered":"http:\/\/www.quintanalab.org\/?p=561"},"modified":"2015-02-01T23:31:03","modified_gmt":"2015-02-02T07:31:03","slug":"our-latest-paper-is-out","status":"publish","type":"post","link":"https:\/\/webs.uab.cat\/mitochondrial-neuropatology\/2015\/02\/01\/our-latest-paper-is-out\/","title":{"rendered":"Our latest paper is out!"},"content":{"rendered":"<p>We are really excited that our latest paper, in collaboration with the <a href=\"http:\/\/flypush.imgen.bcm.tmc.edu\/lab\/about.php\" target=\"_blank\">Bellen lab<\/a> at Baylor, has been published in the prestigious journal <a href=\"http:\/\/www.cell.com\/\" target=\"_blank\">Cell<\/a>.<\/p>\n<p>Our work, titled: <em><strong>Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration<\/strong><\/em>,\u00a0has identified a conserved mechanism that leads to neuronal death after mitochondrial defects.<\/p>\n<p>In this study, the <strong>Bellen lab<\/strong>, using the fruit fly as a model, identified\u00a0that mitochondrial mutations causing reactive oxygen species (aka oxidative stress)\u00a0induced\u00a0\u00a0the accumulation of lipid droplets in glia, the cells that surround and support neurons, via activation of a pathway known as JNK\/SREBP. Lipid droplets are energy storage organelles, especially when neurons are faulty,\u00a0but when these lipid droplets become peroxidated glia is unable to support neurons, leading to their demise.<\/p>\n<figure id=\"attachment_562\" aria-describedby=\"caption-attachment-562\" style=\"width: 300px\" class=\"wp-caption alignleft\"><a href=\"http:\/\/www.quintanalab.org\/wp-content\/uploads\/2015\/02\/fx1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-562 size-medium\" src=\"http:\/\/www.quintanalab.org\/wp-content\/uploads\/2015\/02\/fx1-300x300.jpg\" alt=\"graphical abstract final\" width=\"300\" height=\"300\" srcset=\"https:\/\/webs.uab.cat\/mitochondrial-neuropatology\/wp-content\/uploads\/sites\/617\/2015\/02\/fx1-300x300.jpg 300w, https:\/\/webs.uab.cat\/mitochondrial-neuropatology\/wp-content\/uploads\/sites\/617\/2015\/02\/fx1-150x150.jpg 150w, https:\/\/webs.uab.cat\/mitochondrial-neuropatology\/wp-content\/uploads\/sites\/617\/2015\/02\/fx1.jpg 448w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption id=\"caption-attachment-562\" class=\"wp-caption-text\">Credit: CellPress (cell.com)<\/figcaption><\/figure>\n<p>Our work was key in identifying\u00a0that <strong>this mechanism was present\u00a0in mice<\/strong>, suggesting it has been <strong>evolutionary conserved<\/strong>, highlighting its potential importance.<\/p>\n<p>Finally, we used a potent antioxidant, AD4, that crosses the blood-brain-barrier (which limits the access of many drugs to the brain), and showed that it was able to <strong>reduce and delay the onset of the disease<\/strong>.<\/p>\n<p>We are really excited of the <strong>future therapeutic potential of this approach<\/strong> and we are really happy of this fruitful collaboration (pun intended!).<\/p>\n<p>The article can be accessed <a href=\"http:\/\/www.cell.com\/cell\/abstract\/S0092-8674(14)01589-X\" target=\"_blank\">here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We are really excited that our latest paper, in collaboration with the Bellen lab at Baylor, has been published in the prestigious journal Cell. Our work, titled: Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration,\u00a0has identified a conserved mechanism that leads to neuronal death after mitochondrial defects. In this study, the Bellen [&hellip;]<\/p>\n","protected":false},"author":2072,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13,14],"tags":[],"class_list":["post-561","post","type-post","status-publish","format-standard","hentry","category-articles","category-research"],"_links":{"self":[{"href":"https:\/\/webs.uab.cat\/mitochondrial-neuropatology\/wp-json\/wp\/v2\/posts\/561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/webs.uab.cat\/mitochondrial-neuropatology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/webs.uab.cat\/mitochondrial-neuropatology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/webs.uab.cat\/mitochondrial-neuropatology\/wp-json\/wp\/v2\/users\/2072"}],"replies":[{"embeddable":true,"href":"https:\/\/webs.uab.cat\/mitochondrial-neuropatology\/wp-json\/wp\/v2\/comments?post=561"}],"version-history":[{"count":0,"href":"https:\/\/webs.uab.cat\/mitochondrial-neuropatology\/wp-json\/wp\/v2\/posts\/561\/revisions"}],"wp:attachment":[{"href":"https:\/\/webs.uab.cat\/mitochondrial-neuropatology\/wp-json\/wp\/v2\/media?parent=561"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/webs.uab.cat\/mitochondrial-neuropatology\/wp-json\/wp\/v2\/categories?post=561"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/webs.uab.cat\/mitochondrial-neuropatology\/wp-json\/wp\/v2\/tags?post=561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}