{"id":252,"date":"2023-02-28T22:34:25","date_gmt":"2023-02-28T20:34:25","guid":{"rendered":"https:\/\/webs.uab.cat\/dmrqb\/alejandro-cruz-saez\/"},"modified":"2024-01-01T20:50:34","modified_gmt":"2024-01-01T18:50:34","slug":"alejandro-cruz-saez","status":"publish","type":"page","link":"https:\/\/webs.uab.cat\/molbiomed\/en\/alejandro-cruz-saez\/","title":{"rendered":"Alejandro Cruz S\u00e1ez"},"content":{"rendered":"\n
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\"ORCID<\/a>   <\/p>\n\n\n\n

Alejandro Cruz Saez<\/strong> was born in Barcelona in 1994. He studied the double degree in Physics and Chemistry at the Autonomous University of Barcelona during the period 2013-2017. Subsequently, during the 2017\/2018 academic year, he completed the master\u2019s degree in Atomistic and Multiscale Computational Modeling in Physics, Chemistry and Biochemistry at the University of Barcelona. During the years 2020\/23, he pursued doctoral studies at the Universitat Aut\u00f2noma de Barcelona where he defended the thesis entitled: \u201cBiomolecular simulations of some relevant enzymes in inflammatory processes: 15-LOX, 5-LOX and COX-2. Application to the study of mechanisms and the design of inhibitors\u201d. <\/p>\n\n\n\n

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He is currently doing his first year of postdoctoral work at the same institution. The research topics he is currently working on are the study of reaction mechanisms catalyzed by enzymes and the design of photoswitches with anti-inflammatory properties.<\/p>\n<\/div>\n<\/div>\n\n

Latest Publications<\/h2>\n\n
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ACS Catalysis<\/h1>\n\n\n\n

Theoretical Study of the Arachidonic Acid Conversion into Leukotriene A4<\/sub> Catalyzed by Human 5-Lipoxygenase: Hydroperoxidation and Epoxidation Mechanisms and Arachidonic Acid Active Site Access<\/p>\n\n\n\n

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Molecules<\/h1>\n\n\n\n

Different Structures\u2014Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H<\/em>-indoles and 5-(4-Methoxyphenyl)-1H<\/em>-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?<\/p>\n\n\n\n

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Journal of Medicinal Chemistry<\/h1>\n\n\n\n

N<\/em>-Substituted 5-(1H<\/em>-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action<\/p>\n\n\n\n

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Read More<\/a> <\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Alejandro Cruz Saez was born in Barcelona in 1994. He studied the double degree in Physics and Chemistry at the Autonomous University of Barcelona during the period 2013-2017. Subsequently, during the 2017\/2018 academic year, he completed the master\u2019s degree in Atomistic and Multiscale Computational Modeling in Physics, Chemistry and Biochemistry at the University of Barcelona. […]<\/p>\n","protected":false},"author":2580,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-252","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/webs.uab.cat\/molbiomed\/en\/wp-json\/wp\/v2\/pages\/252","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/webs.uab.cat\/molbiomed\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/webs.uab.cat\/molbiomed\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/webs.uab.cat\/molbiomed\/en\/wp-json\/wp\/v2\/users\/2580"}],"replies":[{"embeddable":true,"href":"https:\/\/webs.uab.cat\/molbiomed\/en\/wp-json\/wp\/v2\/comments?post=252"}],"version-history":[{"count":7,"href":"https:\/\/webs.uab.cat\/molbiomed\/en\/wp-json\/wp\/v2\/pages\/252\/revisions"}],"predecessor-version":[{"id":2320,"href":"https:\/\/webs.uab.cat\/molbiomed\/en\/wp-json\/wp\/v2\/pages\/252\/revisions\/2320"}],"wp:attachment":[{"href":"https:\/\/webs.uab.cat\/molbiomed\/en\/wp-json\/wp\/v2\/media?parent=252"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}