{"id":117,"date":"2023-02-28T22:34:24","date_gmt":"2023-02-28T20:34:24","guid":{"rendered":"https:\/\/webs.uab.cat\/dmrqb\/?page_id=117"},"modified":"2024-12-30T14:29:40","modified_gmt":"2024-12-30T12:29:40","slug":"angels-gonzalez-lafont","status":"publish","type":"page","link":"https:\/\/webs.uab.cat\/molbiomed\/angels-gonzalez-lafont\/","title":{"rendered":"\u00c0ngels Gonz\u00e1lez Lafont"},"content":{"rendered":"\n
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\"ORCID<\/a>   \"RG\"<\/a><\/span><\/p>\n\n\n\n

\u00c0ngels Gonz\u00e1lez Lafont<\/strong> va ser doctora en Ci\u00e8ncies Qu\u00edmiques per la Universitat Aut\u00f2noma de Barcelona (UAB) l’any 1989 i professora d’universitari a la UAB l’any 1992. Catedr\u00e0tica de Qu\u00edmica F\u00edsica a la UAB des de 2011. Directora de 20 Tesis Doctorals (+1 en curs), inclosa una amb Doctorat Industrial en col\u00b7laboraci\u00f3 amb una empresa biotecnol\u00f2gica. Publicaci\u00f3 de 169 articles cient\u00edfics (+4 en l’\u00e0mbit de la doc\u00e8ncia). <\/p>\n\n\n\n

La meva traject\u00f2ria cient\u00edfica va comen\u00e7ar en el camp de la Qu\u00edmica Atmosf\u00e8rica. Vaig utilitzar la teoria de l’estat de transici\u00f3 variacional (VTST), incloses les correccions de t\u00fanel, per calcular les constants de velocitat dels processos qu\u00edmics significatius de degradaci\u00f3 atmosf\u00e8rica iniciats pel radical OH. L’any 2003, la meva recerca va evolucionar cap a les simulacions biomoleculars de cat\u00e0lisi enzim\u00e0tica. Vaig comen\u00e7ar a utilitzar simulacions cl\u00e0ssiques de Din\u00e0mica Molecular utilitzant un model complet de les biomol\u00e8cules amb milers d’\u00e0toms i mol\u00e8cules d’aigua per fer c\u00e0lculs QM\/MM per estudiar les superf\u00edcies d’energia potencial de diferents mecanismes catal\u00edtics que m’han perm\u00e8s tenir un coneixement extens del comportament i la reactivitat de les ciclooxigenases i les lipoxigenases. <\/p>\n\n\n\n

Els meus esfor\u00e7os se centren ara en l’\u00fas de tots els meus coneixements te\u00f2rics de les lipoxigenases (ALOX5, ALOX15 i ALOX12) i COX-2 juntament amb la meva experi\u00e8ncia en metodologies computacionals per modelar sistemes biomoleculars per desenvolupar enfocaments innovadors de Biomedicina Molecular per bloquejar la pro-acci\u00f3 inflamat\u00f2ria d’aquests enzims i activar la seva funci\u00f3 per resoldre els processos inflamatoris que s\u00f3n la causa subjacent de la majoria de c\u00e0ncers. El disseny racional de nous inhibidors de COX-2 i ALOX5 (la majoria de f\u00e0rmacs fotocanviables), el disseny biocatal\u00edtic de s\u00edntesi de MaR1 i en el disseny d’agonistes \u00e9s el centre de la recerca que faig actualment.<\/p>\n<\/div>\n<\/div>\n\n\n\n

\u00daltimes Publicacions<\/h2>\n\n\n\n
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Protein Science<\/h1>\n\n\n\n

First-principles simulations of the fluorescence modulation of a COX-2-specific fluorogenic probe upon protein dimerization for cancer discrimination<\/p>\n\n\n\n

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Llegeix M\u00e9s<\/a><\/p>\n<\/div>\n\n\n\n

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ACS Catalysis<\/h1>\n\n\n\n

Theoretical Study of the Arachidonic Acid Conversion into Leukotriene A4<\/sub> Catalyzed by Human 5-Lipoxygenase: Hydroperoxidation and Epoxidation Mechanisms and Arachidonic Acid Active Site Access<\/p>\n\n\n\n

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Llegeix M\u00e9s<\/a> <\/p>\n<\/div>\n\n\n\n

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Molecules<\/h1>\n\n\n\n

Different Structures\u2014Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H<\/em>-indoles and 5-(4-Methoxyphenyl)-1H<\/em>-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?<\/p>\n\n\n\n

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Llegeix M\u00e9s<\/a> <\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u00c0ngels Gonz\u00e1lez Lafont va ser doctora en Ci\u00e8ncies Qu\u00edmiques per la Universitat Aut\u00f2noma de Barcelona (UAB) l’any 1989 i professora d’universitari a la UAB l’any 1992. Catedr\u00e0tica de Qu\u00edmica F\u00edsica a la UAB des de 2011. Directora de 20 Tesis Doctorals (+1 en curs), inclosa una amb Doctorat Industrial en col\u00b7laboraci\u00f3 amb una empresa biotecnol\u00f2gica. […]<\/p>\n","protected":false},"author":2580,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-117","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/webs.uab.cat\/molbiomed\/wp-json\/wp\/v2\/pages\/117","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/webs.uab.cat\/molbiomed\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/webs.uab.cat\/molbiomed\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/webs.uab.cat\/molbiomed\/wp-json\/wp\/v2\/users\/2580"}],"replies":[{"embeddable":true,"href":"https:\/\/webs.uab.cat\/molbiomed\/wp-json\/wp\/v2\/comments?post=117"}],"version-history":[{"count":13,"href":"https:\/\/webs.uab.cat\/molbiomed\/wp-json\/wp\/v2\/pages\/117\/revisions"}],"predecessor-version":[{"id":2653,"href":"https:\/\/webs.uab.cat\/molbiomed\/wp-json\/wp\/v2\/pages\/117\/revisions\/2653"}],"wp:attachment":[{"href":"https:\/\/webs.uab.cat\/molbiomed\/wp-json\/wp\/v2\/media?parent=117"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}