{"id":379,"date":"2025-10-08T11:31:38","date_gmt":"2025-10-08T09:31:38","guid":{"rendered":"https:\/\/webs.uab.cat\/rna-rnase\/?page_id=379"},"modified":"2025-10-09T13:01:57","modified_gmt":"2025-10-09T11:01:57","slug":"fall-workshop","status":"publish","type":"page","link":"https:\/\/webs.uab.cat\/rna-rnase\/fall-workshop\/","title":{"rendered":"Fall Workshop"},"content":{"rendered":"\n<h1 class=\"wp-block-heading alignfull has-text-align-right has-verd-tropic-color has-text-color has-link-color has-larger-font-size wp-elements-d09339fc249fa866386694165d4898e1\">30th October 2025<\/h1>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-verd-tropic-transparent-background-color has-background is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center has-large-font-size\">15:30-16:15 (CET)<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"has-text-align-center has-larger-font-size\"><strong>Dr. Francesco Acquati<\/strong> <\/p>\n<\/blockquote>\n\n\n\n<div class=\"wp-block-group is-vertical is-content-justification-center is-layout-flex wp-container-core-group-is-layout-4b2eccd6 wp-block-group-is-layout-flex\">\n<p class=\"has-text-align-center\"><br>University of Insubria<\/p>\n<\/div>\n\n\n\n<p class=\"has-text-align-center has-blanc-coco-color has-negre-eben-background-color has-text-color has-background has-link-color wp-elements-2d84217f8f53d681f972972157004a5f\"><strong><a href=\"https:\/\/archivio.uninsubria.it\/hpp\/francesco.acquati\">Department of Biotechnology and Life Sciences<\/a><\/strong><\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-16018d1d wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/webs.uab.cat\/rna-rnase\/fall-workshop\/#Francesco_Acquati\">More details<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-verd-tropic-transparent-background-color has-background is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center has-large-font-size\">16:15-17:00 (CET)<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"has-text-align-center has-larger-font-size\"><strong>Dr. Frank Hern\u00e1ndez<\/strong><\/p>\n<\/blockquote>\n\n\n\n<div class=\"wp-block-group is-vertical is-content-justification-center is-layout-flex wp-container-core-group-is-layout-4b2eccd6 wp-block-group-is-layout-flex\">\n<p class=\"has-text-align-center\">Link\u00f6ping University &amp; TECNUN- Universidad de Navarra<\/p>\n<\/div>\n\n\n\n<p class=\"has-text-align-center has-blanc-coco-color has-negre-eben-background-color has-text-color has-background has-link-color wp-elements-1d9862770ea0f77cff38b89ed5abdf20\"><strong><a href=\"https:\/\/liu.se\/en\/employee\/frahe49\">Department of Physics, Chemistry and Biology<\/a><\/strong><\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-16018d1d wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/webs.uab.cat\/rna-rnase\/fall-workshop\/#Frank_Hern\u00e1ndez\">More details<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator alignfull has-alpha-channel-opacity\" \/>\n\n\n\n<div class=\"wp-block-columns alignfull are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<blockquote class=\"wp-block-quote alignwide is-layout-flow wp-block-quote-is-layout-flow\">\n<h1 class=\"wp-block-heading alignwide has-verd-tropic-color has-gris-pubilla-background-color has-text-color has-background has-link-color has-larger-font-size wp-elements-ab0ae03992678bd0ac95e0ca59717ec2\" id=\"Francesco_Acquati\">Time: 15:30-16:15_<strong><strong>Dr. Francesco Acquati<\/strong><\/strong><\/h1>\n<\/blockquote>\n\n\n\n<details class=\"wp-block-mamaduka-toggles alignwide wp-block-toggles has-larger-font-size\"><summary><strong><strong><strong>Human RNASET2 as a highly pleiotropic tumor suppressive alarmin<\/strong><\/strong><\/strong><\/summary><div class=\"wp-block-toggles__content\">\n<ul class=\"wp-block-list\">\n<li class=\"has-normal-font-size\">&nbsp;The human <em>RNASET2<\/em> gene has been consistently reported to act as a tumor suppressor gene in several <em>in vitro <\/em>and <em>in vivo<\/em> experimental models of cancer. This gene encodes for an evolutionarily conserved and highly pleiotropic extracellular ribonuclease displaying both cell autonomous and non-cell autonomous oncosuppressive activities. In particular, RNASET2 secretion by cancer cells in the tumor microenvironment was shown to trigger tumor suppression by means of recruitment of innate immune response cells endowed with oncoppressive roles (M1-polarized macrophages). These data support a role for RNASET2 acting as an alarmin-like molecule <em>in vivo<\/em> to trigger an innate immune response against cancer cells. Such non cell-autonomous role was recently investigated and validated <em>in vitro <\/em>in two human macrophages experimental models. Furthermore, <em>in vitro<\/em> cell culture systems have also unveiled a concomitant, cell-autonomous function of RNASET2 in stress-related tumor suppression, which turned out to represent an evolutionary conserved feature of this member of the transferase-type RNase family.<\/li>\n\n\n\n<li class=\"has-normal-font-size\">Taken together, these data strongly support the role of T2 RNases as an evolutionary conserved stress-response oncosuppressor protein involved in host defense, which likely represents just one of the multifaceted biological functions carried out by this extremely ancient class of ribonucleases.<\/li>\n<\/ul>\n<\/div><\/details>\n\n\n\n<blockquote class=\"wp-block-quote alignwide is-layout-flow wp-block-quote-is-layout-flow\">\n<h1 class=\"wp-block-heading alignwide has-verd-tropic-color has-gris-pubilla-background-color has-text-color has-background has-link-color has-larger-font-size wp-elements-6b6d744f0c1037c1c3d0c9d4129fe6ba\" id=\"Frank_Hern\u00e1ndez\">Time: 16:15-17:00_<strong><strong>Dr. <strong>Frank Hern\u00e1ndez<\/strong><\/strong><\/strong><\/h1>\n<\/blockquote>\n\n\n\n<details class=\"wp-block-mamaduka-toggles alignwide wp-block-toggles has-larger-font-size\"><summary><strong><strong><strong><strong><strong><strong><strong>RNases, Immunity, and the Tumor Microenvironment<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/summary><div class=\"wp-block-toggles__content\">\n<ul class=\"wp-block-list\">\n<li class=\"has-normal-font-size\">Ribonucleases (RNases) are no longer viewed merely as degradative enzymes but as key mediators of immune activation across diverse human conditions, including cancer. Building upon their evolutionary role in host defense, RNases have emerged as regulators of extracellular RNA turnover and modulators of inflammation within the tumor microenvironment. In this presentation, we will discuss how the concept of nuclease activity as a functional biomarker, previously demonstrated in cancer diagnostics, extends into the immunological landscape of tumors. <\/li>\n\n\n\n<li class=\"has-normal-font-size\">Recent work has revealed that RNases released by immune cells, particularly neutrophils, can shape local immune activation through the generation of short RNA fragments that act as immunostimulatory signals. Together, these findings support a new perspective of RNases as enzymatic indicators and active players in the immune surveillance of cancer.<\/li>\n<\/ul>\n<\/div><\/details>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center has-verd-tropic-transparent-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-pullquote\"><blockquote><p><strong>Teams link for the event<\/strong><\/p><cite>30th October 2025<\/cite><\/blockquote><\/figure>\n\n\n\n<div class=\"wp-block-buttons alignwide is-content-justification-right is-layout-flex wp-container-core-buttons-is-layout-765c4724 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100\"><a class=\"wp-block-button__link has-text-align-center wp-element-button\" href=\"https:\/\/teams.microsoft.com\/l\/meetup-join\/19%3ameeting_OWU1Y2IyOWItNjQzMy00ZDA2LTk0NzYtYzBiZGYxNDQ3NWVj%40thread.v2\/0?context=%7b%22Tid%22%3a%22df4771ae-786c-4f42-9985-67d023afea35%22%2c%22Oid%22%3a%223f1b9631-5ac3-46cc-9195-e6ee18a762cc%22%7d\">LINK<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>30th October 2025 15:30-16:15 (CET) Dr. Francesco Acquati University of Insubria Department of Biotechnology and Life Sciences 16:15-17:00 (CET) Dr. Frank Hern\u00e1ndez Link\u00f6ping University &amp; TECNUN- Universidad de Navarra Department of Physics, Chemistry and Biology Time: 15:30-16:15_Dr. Francesco Acquati Time: 16:15-17:00_Dr. Frank Hern\u00e1ndez Teams link for the event 30th October 2025<\/p>\n","protected":false},"author":2988,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-379","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/webs.uab.cat\/rna-rnase\/wp-json\/wp\/v2\/pages\/379","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/webs.uab.cat\/rna-rnase\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/webs.uab.cat\/rna-rnase\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/webs.uab.cat\/rna-rnase\/wp-json\/wp\/v2\/users\/2988"}],"replies":[{"embeddable":true,"href":"https:\/\/webs.uab.cat\/rna-rnase\/wp-json\/wp\/v2\/comments?post=379"}],"version-history":[{"count":9,"href":"https:\/\/webs.uab.cat\/rna-rnase\/wp-json\/wp\/v2\/pages\/379\/revisions"}],"predecessor-version":[{"id":394,"href":"https:\/\/webs.uab.cat\/rna-rnase\/wp-json\/wp\/v2\/pages\/379\/revisions\/394"}],"wp:attachment":[{"href":"https:\/\/webs.uab.cat\/rna-rnase\/wp-json\/wp\/v2\/media?parent=379"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}