Publications (Last 5 years) – Gene Therapy For Diseases Involving The Central Nervous System- TherCNS

2026

R. Blanch; J. Esandi; R. Guerrero-Yagüe; J. del Rey; J. Roig-Soriano; A. Lleo; E. Carro; N. Mestre-Francés; G. Devau; I. Ferrer; A. Meseguer; JL. Lanciego; B. Almolda; A. Bosch; M. Chillón (2026). Long-term effects of s-KL treatment in wild-type mice, enhancing longevity, physical well-being, and neurological resilience. Genes and Diseases. in press.

Chocarro J, Marana S, Espelosin M, Rico AJ, Ariznabarreta G, Lorenzo-Ramos E, Ilarduya MM, Hernandez-Alcoceba R, Chillón M, Vila M, Kordower JH, Schapira AHV, Garcia-Osta A, Cuadrado-Tejedor MDM, Lanciego JL. (2026). Introducing PIGMO, a novel PIGmented MOuse model of Parkinson’s disease. NPJ Parkinson’s Disease. Feb 11. doi: 10.1038/s41531-026-01289-9

Muscolino E, Puig-Torrents M, Buigues Bisquert J, Correa Mendonca D, Talló-Parra M, Perez-Vilaro G, Caño-Prades O, Meehan GR, Kerr K, Herder V, Chillón M, Castello A, Sanjuan R, Patel AH, Díez J. (2026). Coronaviruses reprogram the tRNA epitranscriptome to favor viral protein expression. Nature Communication. Feb 19. doi: 10.1038/s41467-026-69700-w

A. Brao, A. Sánchez, I. Rodríguez J. del Rey,Silvia Lope-Piedrafita, E. Prat, V. Nunes, M. Chillón, R. Estévez, and A. Bosch. (2025). Gene therapy rescues brain edema and motor function in a mouse model of megalencephalic leukoencephalopathy with subcortical cysts. Molecular Therapy. 33(4):1434-1448. doi: 10.1016/j.ymthe.2025.02.046

Roig-Soriano J, Edo A, Verdés S, Martín-Alonso C, Sánchez-de-Diego C, Rodriguez-Estevez L, Serrano AL, Abraham CR, Bosch A, Ventura F, Jordan BA, Muñoz-Cánoves P; Chillón M. (2025). Long-term effects of s-KL treatment in wild-type mice, enhancing longevity, physical well-being, and neurological resilience. Molecular Therapy. 33(4):1449-1465. doi: 10.1016/j.ymthe.2025.02.030

J. Esandi; P. Renault; M. Dolores Capilla-López; R. Blanch; A. Edo; D. Ramirez-Gomez; A. Bosch; B. Almolda; C.A. Saura; J. Giraldo; M. Chillón. (2025). HEBE: a novel chimeric chronokine for ameliorating memory deficits in Alzheimer’s disease. Biomedicine and Pharmacotherapy. Feb:183:117815. doi: 10.1016/j.biopha.2025.117815

Ciudad CJ, Valiuska S, Rojas JM, Nogales-Altozano P, Aviñó A, Eritja R, Chillón M, Sevilla N, Noé V. (2024). Polypurine Reverse Hoogsteen hairpins as a therapeutic tool for SARS-CoV-2 infection. J Biol Chem. Oct 10:107884. doi: 10.1016/j.jbc.2024.107884
Bunuales M, Garduno A, Chillon M, Bosch A, Gonzalez-Aparicio M, Espelosin M, Garcia-Gomara M, Rico A.J, Garcia-Osta A, Cuadrado-Tejedor M, Lanciego J.L, Hernandez-Alcoceba R. (2024). Characterization of brain transduction capability of a BBB-penetrant AAV vector in mice, rats and macaques reveals differences in expression profiles. Gene Therapy. Sep;31(9-10):455-466. doi.org/10.1038/s41434-024-00466-w
Fitzgerald M.Q, Chu T, Puppo F, Blanch R, Chillón M, Subramaniam S, Muotri A. (2024). Protocol for Generation of Semi-guided Cortical Organoids with Complex Neural Oscillations. Nature Protocols. Sep;19(9):2712-2738. doi.org/10.1038/s41596-024-00994-0
Favaro MTP, Alamo P, Roher N, Chillon M, Lascorz J, Márquez M, Corchero JL, Mendoza R, Martínez-Torró C, Ferrer-Miralles N, Ferreira LCS, Mangues R, Vázquez E, Parladé E, Villaverde A. (2024). Adjuvant-free microscale granules made of the SARS-CoV-2 spike protein trigger an anti-virus neutralizing response. ACS Materials Letters, 6:954-962. doi.org/10.1021/acsmaterialslett.3c01643

Roig-Soriano, J., Sánchez-de-Diego, C., Esandi-Jauregui, J., Verdés, S., Abraham, C. R., Bosch A, Ventura, F., Chillon M (2023). Differential toxicity profile of secreted and processed α-Klotho expression over mineral metabolism and bone microstructure. Scientific Reports, 13(1):4211. doi.org/10.1038/s41598-023-31117-6

Leal-Julià M, Vilches J, Onieva A, Verdés S, Sánchez A, Chillón M, Navarro X, Bosch A. Proteomic quantitative study of dorsal root ganglia and sciatic nerve in type 2 diabetic mice. Molecular Metabolism (2022), 55: 101408. doi.org/10.1016/j.molmet.2021.101408.
Edo, Á., Calvo-Barreiro, L., Eixarch, H., Bosch, A., Chillón, M., & Espejo, C. (2022). Therapeutic Effect of IL-21 Blockage by Gene Therapy in Experimental Autoimmune Encephalomyelitis. Neurotherapeutics, 19(5), 1617-1633. doi.org/10.1007/s13311-022-01279-8
Roig-Soriano, J., Griñán-Ferré, C., Espinosa-Parrilla, J. F., Abraham, C. R., Bosch, A., Pallàs, M., & Chillón, M. (2022). AAV-mediated expression of secreted and transmembrane αKlotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice. Aging Cell, 21(4), Article e13581. https://doi.org/10.1111/acel.13581