{"id":237,"date":"2024-02-21T13:35:54","date_gmt":"2024-02-21T11:35:54","guid":{"rendered":"https:\/\/webs.uab.cat\/therCNS\/?page_id=237"},"modified":"2024-03-09T12:15:44","modified_gmt":"2024-03-09T10:15:44","slug":"molecular-mechanisms-involved-in-memory-formation","status":"publish","type":"page","link":"https:\/\/webs.uab.cat\/therCNS\/molecular-mechanisms-involved-in-memory-formation\/","title":{"rendered":"Natural and chimeric chronokines for age-associated disorders"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>Aging is a multifactorial process resulting in the progressive and irreversible time-dependent fragility and deterioration of biological functional drivers that typically keep organs and tissues healthy. In this complex scenario, <strong>our group has a contrasted experience in the field of anti-aging strategies<\/strong>. Specifically, our research is based on the use of chronokines (as the <strong>secreted Klotho -sKL- isoform<\/strong>), key biological drivers during aging, as an approach to improve biological functions related to physiological aging and age-associated pathologies. <\/p>\n<\/blockquote>\n\n\n\n<p>In the last years, our group has reported that:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>sKL is expressed in the brain regions involved in memory processes like the hippocampus and cortex, and its level is associated with cognitive decline, decreasing 5-8 times faster in pathological aging such as in Alzheimer&#8217;s Disease (AD) than in healthy aging. This reduction is already evident in the early stages of AD, even before the apparition of beta-amyloid plaques <em>(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4658185\/\" data-type=\"link\" data-id=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4658185\/\">Masso A et al. 2015. PloS one. 10:e0143623<\/a>)<\/em><strong>.<\/strong><\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\"><div class=\"wp-block-image\">\n<figure class=\"alignleft size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"762\" src=\"https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-23-a-las-18.39.02-1024x762.png\" alt=\"\" class=\"wp-image-390\" style=\"width:305px;height:auto\" srcset=\"https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-23-a-las-18.39.02-1024x762.png 1024w, https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-23-a-las-18.39.02-300x223.png 300w, https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-23-a-las-18.39.02-768x571.png 768w, https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-23-a-las-18.39.02.png 1046w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"798\" height=\"790\" src=\"https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-22-a-las-15.21.12.png\" alt=\"\" class=\"wp-image-363\" style=\"width:314px;height:auto\" srcset=\"https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-22-a-las-15.21.12.png 798w, https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-22-a-las-15.21.12-300x297.png 300w, https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-22-a-las-15.21.12-768x760.png 768w\" sizes=\"auto, (max-width: 798px) 100vw, 798px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Just a single in vivo administration of AAVs expressing sKL resulted in long-lasting and quantifiable enhancement of memory performance in old mice and primates<em>(<a href=\"https:\/\/www.nature.com\/articles\/mp2017211\" data-type=\"link\" data-id=\"https:\/\/www.nature.com\/articles\/mp2017211\">Mass\u00f3 A et al. 2018. Mol Psychiatry. 23(9):1-11<\/a> &amp; patent EP15195470.8)<\/em>. <\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>sKL also protects cognitive performance in an animal model of ALS <em>(patent US-63\/330.684)<\/em>. <\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Long-term expression of sKL increase longevity by ~25% in rodents <em>(patent EP22383171.0)<\/em>.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>sKL can rejuvenate the epigenetic profile of neurons in vivo <em>(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9009104\/\" data-type=\"link\" data-id=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9009104\/\">Roig-Soriano J, et al.2022. Aging Cell. 21(4):e13581<\/a>; &amp; patent EP22383171.0)<\/em>. <\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"630\" height=\"402\" src=\"https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-23-a-las-18.45.10-1.png\" alt=\"\" class=\"wp-image-398\" style=\"width:296px;height:auto\" srcset=\"https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-23-a-las-18.45.10-1.png 630w, https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-23-a-las-18.45.10-1-300x191.png 300w\" sizes=\"auto, (max-width: 630px) 100vw, 630px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"774\" height=\"568\" src=\"https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-23-a-las-18.48.34.png\" alt=\"\" class=\"wp-image-399\" srcset=\"https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-23-a-las-18.48.34.png 774w, https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-23-a-las-18.48.34-300x220.png 300w, https:\/\/webs.uab.cat\/therCNS\/wp-content\/uploads\/sites\/458\/2024\/02\/Captura-de-pantalla-2024-02-23-a-las-18.48.34-768x564.png 768w\" sizes=\"auto, (max-width: 774px) 100vw, 774px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>sKL long-term expression increases bone density, and reduces bone fragility and osteopenia <em>(patent WO2022\/243519)<\/em>, as well as it increases muscle strength, and reduces sarcopenia <em>(patent EP22383173.6)<\/em>.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Together with the spin-off Kogenix Therapeutics and the Institute of Oncology in Tel Aviv we have observed that Klotho does not induce tumors but have tumor-suppressor activity <em>(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8699737\/\">Arbel T, 2021. Cancers. 13(24): 6297<\/a>;  &amp; patent IL2019\/050913)<\/em>.<\/li>\n<\/ul>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Aging is a multifactorial process resulting in the progressive and irreversible time-dependent fragility and deterioration of biological functional drivers that typically keep organs and tissues healthy. In this complex scenario, our group has a contrasted experience in the field of anti-aging strategies. Specifically, our research is based on the use of chronokines (as the secreted [&hellip;]<\/p>\n","protected":false},"author":2848,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-237","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/webs.uab.cat\/therCNS\/wp-json\/wp\/v2\/pages\/237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/webs.uab.cat\/therCNS\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/webs.uab.cat\/therCNS\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/webs.uab.cat\/therCNS\/wp-json\/wp\/v2\/users\/2848"}],"replies":[{"embeddable":true,"href":"https:\/\/webs.uab.cat\/therCNS\/wp-json\/wp\/v2\/comments?post=237"}],"version-history":[{"count":25,"href":"https:\/\/webs.uab.cat\/therCNS\/wp-json\/wp\/v2\/pages\/237\/revisions"}],"predecessor-version":[{"id":947,"href":"https:\/\/webs.uab.cat\/therCNS\/wp-json\/wp\/v2\/pages\/237\/revisions\/947"}],"wp:attachment":[{"href":"https:\/\/webs.uab.cat\/therCNS\/wp-json\/wp\/v2\/media?parent=237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}