Intergenerational transmission of psychopathology: Effects of parental genotypes

Research project description PhD will investigate mechanisms underlying the intergenerational transmission of risk for psychopathology and mental disorders (parental genotypes).  There is evidence supporting that psychopathology is transmitted across generations. Children with parents with high rates of psychopathology are more likely to inherit both psychopathology-associated genetic factors and psychopathology-associated environments. However, it remains challenging to […]

Developing New Models and Measures of Genetic and Psychological Sensitivity to the Psychosocial Environment to Understand both Risk and Resilience in Mental Health

Research project description Mental health disorders, including psychosis-spectrum phenotypes, are expressed across a dynamic continuum from nonclinical to clinical manifestations. Transition across the continuum is driven by genetic factors (G), person factors (P), environmental exposures (E), and their interactions. Research has investigated GxE interactions in psychosis, but only from a diathesis-stress model, focusing solely on […]

Molecular determinants of sex-specific vulnerability to neuropsychiatric symptoms and cognitive disability during aging

Research project description PhD will investigate the molecular profiles associated with sex-specific vulnerability to dementia and neuropsychiatric disorders during aging.   Mental health disorders, including anxiety and depression, affect disproportionally more women than men and are associated with increased risk of cognitive disability and dementia during normal and pathological aging. Strategies to develop novel precision diagnostics […]

Integrative Omics and Neuroimaging of Treatment Resistance in Psychiatric Disorders: An AI Approach

Research project description PhD will investigate treatment response in MDD, schizophrenia, and other mental disorders which do not respond to available strategies, focusing on novel therapies like neuromodulation, remediation, and psychotherapy.  Treatment-resistant neuropsychiatric disorders demand innovative treatment strategies. Our 3-year PhD project aims to decode treatment response in MDD, schizophrenia, and other mental disorders which […]