Group publications

2024

• Harnessing alkaline-pH regulatable promoters for efficient methanol-free expression of enzymes of industrial interest in Komagataella phaffii (2024) Microbial Cell Factories 23(1): 99. doi: 10.1186/s12934-024-02362-9

2023

• Bravo-Alonso, I.; Morin, M.; Arribas-Carreira, L.; Álvarez, M.; Pedrón-Giner, C.; Soletto, L.; Santolaria, C.; Ramón-Maiques, S.; Ugarte, M.; Rodríguez-Pombo, P.; Ariño, J.; Moreno-Pelayo, M.A.; Pérez, B. (2023) Pathogenic variants of the coenzyme A biosynthesis-associated enzyme phosphopantothenoylcysteine decarboxylase (PPCDC) cause autosomal-recessive dilated cardiomyopathy. Journal of Inherited Metabolic Disease. 46(2):261-272. doi: 10.1002/jimd.12584
• Albacar, M; Zekhnini, A.; Pérez-Valle, J.; Martínez, J.L., Casamayor, A.; Ariño, J. (2023) Transcriptomic profiling of the yeast Komagataella phaffii in response to environmental alkalinization. Microbial Cell Factories. 22(1):63. doi: 10.1186/s12934-023-02074-6.
• The ENA1 Na+-ATPase Gene Is Regulated by the SPS Sensing Pathway and the Stp1/Stp2 Transcription Factors. Int. J. Mol. Sci. 2023, 24, 5548. https://doi.org/10.3390/ijms24065548.

2022

• 2022, Casamayor, Antonio i Ariño, Joaquín. When Phosphatases Go Mad: The Molecular Basis for Toxicity of Yeast Ppz1.. Int J Mol Sci 23
• 2022, Casamayor, Antonio, Ariño, Joaquín, Højrup, Peter, Rasmussen, Morten I, Albacar, Marcel, Santolaria, Carlos, i Velázquez, Diego. Comparative Analysis of Type 1 and Type Z Protein Phosphatases Reveals D615 as a Key Residue for Ppz1 Regulation.. Int J Mol Sci 23
• 2022, Albacar, Marcel, Ariño, Joaquín, Casamayor, Antonio, i Velázquez, Diego. The toxic effects of yeast Ppz1 phosphatase are counteracted by subcellular relocalization mediated by its regulatory subunit Hal3.. FEBS Lett

2021

• 2021, Flores, Carmen-Lisset, Gancedo, Carlos, i Ariño, Joaquín. The N-Acetylglucosamine Kinase from Is a Moonlighting Protein.. Int J Mol Sci 22
• 2021, Albacar, Marcel, Zimmermannova, Olga, Ariño, Joaquín, Casamayor, Antonio, Velázquez, Diego, Calafí, Carlos, i Sacka, Lenka. The Toxic Effects of Ppz1 Overexpression Involve Nha1-Mediated Deregulation of K and H Homeostasis.. J Fungi (Basel) 7

2020

• 2020, Calafí, C, Ariño, J., Casamayor, A, Albacar, M, i López-Malo, M. The N-terminal region of yeast protein phosphatase Ppz1 is a determinant for its toxicity. International Journal of Molecular Sciences 21 (7733) 1-16
• 2020, Casamayor, A. i Ariño, J.. Controlling Ser/Thr protein phosphatase PP1 activity and function through interaction with regulatory subunits. Enzymes – Mechanisms, Dynamics and Inhibition. 122 231-288
• 2020, Calafí, Carlos, Casamayor, Antonio, Ariño, Joaquín, de la Cruz, Jesús, Rodríguez-Galán, Olga, Fernández-Fernández, José, Zhang, Chunyi, Velázquez, Diego, i López-Malo, María. Overexpression of budding yeast protein phosphatase Ppz1 impairs translation.. Biochim Biophys Acta Mol Cell Res 1867 118727
• 2020, Velázquez, D., Ariño, J., Casamayor, A., Daignan-Fornier, B., Jensen, O.N., Pinson, B., Kovalchuk, S.I., Martí, R., Torres-Torronteras, J., López-Malo, M., Calafí, C., Zhang, C., i Albacar, M.. Yeast Ppz1 protein phosphatase toxicity involves the alteration of multiple cellular targets. Scientific Reports 10 (15613) 1-21

2019

• 2019, Zhang, C, Ariño, J, Pérez-Martín, J., i de la Torre, A.. Protein phosphatase Ppz1 is not regulated by a Hal3-like protein in plant pathogen Ustilago maydis.. International Journal of Molecular Sciences 20 1-19
• 2019, Ariño, Joaquín, Casamayor, Antonio, i Velázquez, Diego. Ser/Thr protein phosphatases in fungi: structure, regulation and function. Microbial Cell 6 217-256
• 2019, Zhang, Chunyi, Ariño, J, Zaragoza, O, Reverter, D, Tabernero, L, de Oliveira, HC, Molero, C, i García-Rodas, R. Characterization of the atypical Ppz/Hal3 phosphatase system from the pathogenic fungus Cryptococcus neoformans. Molecular Microbiology 111 898-917
• 2019, Ariño, J, Sychrova, H., i Ramos, J. Monovalent cation transporters at the plasma membrane in yeasts. Yeast 36 177-193

2018

• 2018, Santolaria, C,, Ariño, J., Strauss, E., i Velázquez, D.. Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function. Scientific Reports 8 14701
• 2018, Trevijano-Contador, N., Zaragoza, O., Ariño, J., Janbon, G., Zaballos, A., Llorente, I, Rossi, S.A., García-Rodas, R., i Cesar de Oliveira, H.. Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals. PLOS Pathogens 14(5)

2017

• 2017, Peris-Peris, C., San Segundo, B., Ariño, J., Campo, S., Sánchez-Sanuy, F, i Serra-Cardona, A.. Two distinct NRAMP6 isoforms function as iron and manganese transporters and contribute to disease resistance in rice. Molecular Plant-Microbe Interactions 30 385-398
• 2017, Molero, C., Ariño, J., i Casado, C.. The inhibitory mechanism of Hal3 on the yeast Ppz1 phosphatase: A mutagenesis analysis. Scientific Reports 7:8819 1-14

2016

• 2016, Bru, S., Clotet, J., Ariño, J., Canadell, D., i Jiménez, J.. Improvement of biochemical methods of polyP quantification. Microbial Cell 4 6-15
• 2016, Pérez-Sampietro, M, E. Herrero, J. Ariño, C. Casas, D. Canadell, i Serra-Cardona, A.. The yeast Aft2 transcription factor determines selenite toxicity by controlling the low affinity phosphate transport system. Sci Rep. 6 1-14
• 2016, Roque, A., J. Ariño, Serra-Cardona, A., i S. Petrezsélyová. Genome-wide recruitment profiling of transcription factor Crz1 in response to high pH stress. BMC Genomics 17 1-10
• 2016, K. Petrényi, V. Dombrádi, J. Ariño, Erdődi, F., Kónya, Z., i Molero, C.. Analysis of Two Putative Candida albicans Phosphopantothenoylcysteine Decarboxylase / Protein Phosphatase Z Regulatory Subunits Reveals an Unexpected Distribution of Functional Roles.. PLoS One 11
• 2016, Petrezselyova, S., Ariño J., Yenush, L., Alves, R., Vilaprinyó, E., Marqués, Mª C., Serra-Cardona, A., Roque, A., D. Canadell, i López-Malo, M.. Regulation of the Na+/K+-ATPase Ena1 Expression by Calcineurin/Crz1 under High pH Stress: A Quantitative Study.. Plos One 11
• 2016, Popa, C., Valls, M., J. Ariño, Coll, NS., Tabuchi, M., Hashii, K., Tatjer, L., Gil, S., i Li, L.. The effector AWR5 from the plant pathogen Ralstonia solanacearum is an inhibitor of the TOR signalling pathway.. Sci Rep. 6 1-17
• 2016, Tatjer, L., J. Ariño, A. Casamayor, A. Barceló, Serra-Cardona, A., i González, A. The Saccharomyces cerevisiae Ptc1 protein phosphatase attenuates G2-M cell cycle blockage caused by activation of the cell wall integrity pathway. Molecular Microbiology 101(4):. doi: 671-687
• 2016, S. Bru, J. Clotet, J. Jiménez, S. Sharma, J. Ariño, D. Canadell, R. Martí, J. Torres-Torronteras, M. Rafel J., E. Quandt, S. Hernández-Ortega, i J.M. Martínez. Polyphosphate is Involved in Cell Cycle Progression and Genomic Stability in Saccharomyces. Molecular Microbiology 101 367-80
• 2016, Castells Domingo, X., Arús, C., J. Ariño, A. Barceló, Boluda, S., Gabarrós, A., Fernández-Coello, A., Simões, RV., Candiota, AP., Davila, M., i Ferrer-Font, L.. Improving Ribosomal RNA Integrity in Surgically Resected Human Brain Tumor Biopsies.. Biopreservation and Biobanking 14 156-64
• 2016, D. Canadell i J. Ariño. Interactions Between Monovalent Cations and Nutrient Homeostasis. Membrane Transport in Yeast 892 271-89
• 2016, Tatjer, L., J. Ariño, Molina, M., Martín, H., Serra-Cardona, A., D. Canadell, Palacios,L., Rodríguez-Porrata, B., González, A, Casado, C, i Sacristán-Reviriego, A.. Wide-Ranging Effects of the Yeast Ptc1 Protein Phosphatase Acting Through the MAPK Kinase Mkk1.. Genetics 202 141-156

2015

• 2015, J.A. Abrie, E. Strauss, J. Ariño, i Molero, C.. Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3. Scientific Reports in press.
• 2015, Fernández-Niño, M., J. Ariño, Nevoigt, E., Rodríguez-Porrata, B., Swinnen, S., i M. Marquina. Cytosolic pH of individual Saccharomyces cerevisiae cells is a key factor for acetic acid tolerance. Applied and Environmental Microbiology in press.
• 2015, Daniel Pastor-Flores, Antonio Casamayor, Ricardo M. Biondi, Martí Boleda, Anna Bahí, i Jofre Ferrer-Dalmau. Depletion of yeast PDK1 orthologs triggers a stress-like transcriptional response. BMC Genomics 16
• 2015, Serra-Cardona, A., J. Ariño, i D. Canadell. Coordinate responses to alkaline pH stress in budding yeast. Microbial Cell 2 182-196
• 2015, D. Canadell, J. Ariño, Pérez-Ortín, J.E., Alepuz, P., i García-Martínez, J.. Impact of high pH stress on yeast gene expression. A comprehensive analysis of the mRNA turnover during stress responses. Biochem. Biophys. Acta (Gene Regulation) In press.
• 2015, Ferrer-Dalmau, J., A. Casamayor, Prieto, J.A., Marquina, M, i Randez-Gil, F.. Protein kinase Snf1 is involved in the proper regulation of the unfolded protein response in Saccharomyces cerevisiae.. Biochemical Journal 468 33-47
• 2015, Castells, X, Arús, C., A. Barceló, J. Ariño, Candiota, A.P., Julià-Sapé, M., Boluda, S., Majós, C., i Acebes, J.J.. Robustness of equations that define molecular subtypes of glioblastoma tumors based on five transcripts measured by RT-PCR. OMICS 19
• 2015, D. Canadell, J. Ariño, Casado, C, i González, A. Functional interactions between potassium and phosphate homeostasis in Saccharomyces cerevisiae. Mol. Microbiol. 95 555–572

2014

• 2014, Serra-Cardona, A., J. Ariño, J. Ramos, D. Canadell, i S. Petrezsélyová. Co-regulated expression of Na+/phosphate Pho89 transporter and Ena1 Na+-ATPase allows their functional coupling under high pH stress. Mol. Cell. Biol. 34 4420-4435
• 2014, Ariño, J,, et al, Ganser,, Drulhe, S., i Aydar, E.. Systems Biology of Monovalent Cation Homeostasis in Yeast: The Translucent Contribution.. Advances in Microbial Physiology 64 1-63

2013

• 2013, Pastor-Flores, D., Biondi, R.M., A. Casamayor, Süss, E., Engel, M., Passeron, S., Ferrer-Dalmau, J., Giacometti, R., Bahí, A., i Schulze, J.O.. PIF-pocket as a target for C. albicans Pkh selective inhibitors. ACS Chem Biol. 18
• 2013, Molero, C., J. Ariño, Hidalgo, E., Dombradi, V., J. Ramos, E. Strauss, J.A. Abrie, Gelis, S., Carmona, M., González, A, i K. Petrényi. The Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities. Molecular Microbiology 90 367-82
• 2013, González, A, A. Casamayor, J. Ariño, i Casado, C. Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae. PLOS One 8 e64470.
• 2013, González, A, J. Ariño, A. Ruiz, S. Petrezsélyová, i Casado, C. Molecular analysis of a conditional hal3 vhs3 yeast mutant links potassium homeostasis with flocculation and invasiveness. Fungal Genetics and Biology 53 1-9
• 2013, J. Ariño, Dopazo, J, Santoyo, J, Marbà, M, Álvarez-Tejado, M, Pedrola, L, Perez-Pérez, J, i A. Casamayor. Assessing differential expression measurements by highly parallel pyrosequencing and DNA microarrays: a comparative study. OMICS: A Journal of Integrative Biology 15 1-7

2012

• 2012, L. Barreto, J. Ariño, A. Casamayor, Valverde-Saubí, D, i D. Canadell. The short-term response of yeast to potassium starvation. Environmental Microbiology In press
• 2012, Ikram Zaidi, Moez Hanin, Joaquín Ariño, Khaled Masmoudi, José Ramos, Majdi Touzri, i Asier González. The wheat MAP kinase phosphatase 1 confers higher lithium tolerance in yeast. FEMS Yeast Research In press
• 2012, M. Marquina, J. Ariño, A. Casamayor, i Queralt, E. Lack of the Glc7 phosphatase regulatory subunit Ypi1 activates the morphogenetic checkpoint. International Journal of Biochemistry and Cell Biology In press
• 2012, Leiter, E, V. Dombrádi, I. Pócsi, J. Ariño, Hamari, Z, I.L. Farkas, M. Molnár, Miskei, M, Oláh, J, C. Ádám, L. Kovács, Casado, C, E. Erdei, i González, A. Protein phosphatase Z modulates oxidative stress response in fungi. Fungal Genet. Fungal Genetics and Biology In press
• 2012, Kahm, M, Kschischo, M, J. Ramos, J. Ariño, Yenush, L., L. Barreto, R. Herrera, Llopis-Torregrosa, V, i C. Navarrete. Potassium starvation in yeast: Mechanisms of homeostasis revealed by mathematical modeling. PLOS Computational Biology In press
• 2012, Xavier Castells, Carles Arús, Anna Barceló, Joaquín Ariño, Ana Paula Candiota, Margarida Julià-Sapé, Susana Boluda, Carles Majós, i Juan José Acebes. Development of robust discriminant equations for assessing subtypes of glioblastoma biopsies. British Journal of Cancer 106 1816-25
• 2012, Samuel Gelis, José Ramos, Jesús Jorrín, Joaquín Ariño, Asier González, Luis Valledor, i Miguel Curto. Adaptation to potassium starvation of wild type and K+-transport mutant (trk1,2) of Saccharomyces cerevisiae: 2-DE based proteomic approach. MicrobiologyOpen In press
• 2012, A. Casamayor, J. Ariño, A. Ruiz, Casado, C, Platara, M, i R. Serrano. The role of the Snf1 kinase in the adaptive response of Saccharomyces cerevisiae to alkaline pH stress. Biochemical Journal 444 39-49
• 2012, C. Ádám, V. Dombrádi, J. Ariño, I. Pócsi, M. Molnár, I.L. Farkas, P. Bagossi, K. Petrényi, L. Majoros, González, A, L. Kovács, Casado, C, i E. Erdei. Protein phosphatase CaPpz1 is involved in cation homeostasis, cell wall integrity and virulence of Candida albicans. Microbiology (UK) 158 1258-67
• 2012, M. Marquina, J. Ariño, J. Ramos, M.C. Álvarez, A. Ruiz, I. Muñoz, L. Barreto, i González, A. Modulation of yeast alkaline cation tolerance by Ypi1 requires calcineurin. Genetics 190 1355-64
• 2012, T.A.K. Prescott, M.S.J. Simmonds, G.C. Kite, i J. Ariño. Inhibition of human calcineurin and yeast calcineurin-dependent gene expression by Jasminum humile leaf and root extracts. Ethnopharmacology 140 293-297
• 2012, J.A. Abrie, J. Ariño, E. Strauss, i González, A. Functional Mapping of the Disparate Activities of the Yeast Moonlighting Protein Hal3. Biochemical J 442 357-368

2011

• 2011, L. Barreto, J. Ariño, J. Ramos, L. Yenus, Sychrová, H, J. Giraldo, I. Olier, R. Herrera, J. Peréz-Valle, L. Maresová, C. Navarrete, S. Petrezsélyová, i D. Canadell. A genomewide screen for tolerance to cationic drugs reveals genes important for potassium homeostasis in Saccharomyces cerevisiae. Eukaryot Cell 10 1241-50
• 2011, J. Ramos, Sychrová, H, i J. Ariño. Alkali-metal-cation influx and efflux systems in nonconventional yeast species. FEMS Microbiology Letters 317 1-8
• 2011, J. Ariño, Gonzalez, A, i A. Casamayor. Type 2C protein phosphatases in fungi. Eukaryotic Cell 10 21-33
• 2011, Tortosa,R, J. Ariño, Pumarola, M, Torres, JM, A. Barceló, Sánchez, A, Ruiz de Villa, MC, Costa, C, Vidal, E, i Castells, X. Central Nervous System gene expression changes in a transgenic mouse model of Bovine Spongiform Encephalopathy. Veterinary Research In press
• 2011, Casado, C, J. Ariño, A. Ruiz, Platara, M, i González, A. The Role of The Protein Kinase-A Pathway in the Response to Alkaline pH Stress in Yeast. Biochemical J 438 523-533
• 2011, Porcar, M, Urchueguía, J, Vilanova, C, Moya, A, J. Ariño, González, A, Fernández de Córdoba, P, Montagud, A, Navarro, E, Domínguez-Escribà, L, Rivera, S, Szablowski, J, Crespo, J, Otero, E, Pitarch, M, Marco, G, Palanca, C, i Hueso, A. Aequorin-expressing yeast emits light under electric control. J. Biotechnol 152 93-95

2010

• 2010, Clara Navarrete, José Ramos, Hana Sychrová, Joaquín Ariño, Jaromír Zahrádka, José L Martínez, Lina Barreto, i Silvia Petrezsélyová. Lack of main K+ uptake systems in Saccharomyces cerevisiae cells affects yeast performance in both potassium-sufficient and potassium-limiting conditions.. FEMS Yeast Res 10 508–517
• 2010, María Guirola, Joaquin Ariño, Silvia Atrian, Antonio Casamayor, Miriam Romagosa, Ayelen Pagani, i Lina Barreto. Lack of DNA helicase Pif1 disrupts zinc and iron homeostasis in yeast.. Biochem J 423 595-605
• 2010, Jofre Ferrer-Dalmau, Antonio Casamayor, Joaquín Ariño, José Ramos, Lina Barreto, José L Martínez, Clara Navarrete, Maria Platara, i Asier González. Ref2, a regulatory subunit of the yeast protein phosphatase 1, is a novel component of cation homoeostasis.. Biochem J 426 355–364
• 2010, Xavier Castells, Carles Arús, Anna Barceló, Joaquín Ariño, Ana Paula Candiota, Margarida Julià-Sapé, Jesús Pujol, Angel Moreno-Torres, Susana Boluda, i Juan José Acebes. Development of a predictor for human brain tumors based on gene expression values obtained from two types of microarray technologies.. OMICS 14 157–164
• 2010, Carlos Casado, José Ramos, Joaquín Ariño, Jorge Pérez-Valle, Raquel Serrano, María del Carmen Ruiz, Carmen Melero, i Lynne Yenush. Regulation of Trk-dependent potassium transport by the calcineurin pathway involves the Hal5 kinase.. FEBS Lett 584 2415–2420
• 2010, Joaquín Ariño, Hana Sychrová, i José Ramos. Alkali metal cation transport and homeostasis in yeasts.. Microbiol Mol Biol Rev 74 95–120
• 2010, Joaquín Ariño. Integrative responses to high pH stress in S. cerevisiae.. OMICS 14 517–523
• 2010, Jorge Pérez-Valle, Lynne Yenush, Ramón Serrano, José Miguel Mulet, Amparo Pascual-Ahuir, Joaquin Ariño, Mar Martínez Pastor, Cecilia Primo, i Jessica Rothe. The Hal4 and Hal5 protein kinases are required for the general control of carbon and nitrogen uptake and metabolism.. Eukaryot Cell 9 1881-1890

2009

• 2009, Amparo Ruiz, Joaquín Ariño, Erick Strauss, J. Albert Abrie, Raquel Serrano, Ivan Muñoz, i Asier González. Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis.. Nat Chem Biol 5 920–928
• 2009, Asier González, Joaquín Ariño, Antonio Casamayor, i Amparo Ruiz. Normal function of the yeast TOR pathway requires the type 2C protein phosphatase Ptc1.. Mol Cell Biol 29 2876–2888
• 2009, Hélène Gaillard, Andrés Aguilera, Sebastián Chávez, José Luis Revuelta, Joaquín Ariño, Antonio Marín, Alfonso Rodríguez-Gil, María L García-Rubio, Laia Viladevall, Maria José Quintero, Cristina González-Aguilera, Javier Botet, i Cristina Tous. Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair.. PLoS Genet 5 e1000364
• 2009, Xavier Castells, Carles Arús, Joaquín Ariño, Montserrat Robles, Anna Barceló, Susana Boluda, Oscar Godino, Juan José Acebes, Alfredo Navarro, i Juan Miguel García-Gómez. Automated brain tumor biopsy prediction using single-labeling cDNA microarrays-based gene expression profiling.. Diagn Mol Pathol 18 206–218

2008

• 2008, Amparo Ruiz, Joaquín Ariño, i Raquel Serrano. Direct regulation of genes involved in glucose utilization by the calcium/calcineurin pathway.. J Biol Chem 283 13923–13933
• 2008, Jordi Moreno-Romero, M. Carmen Martínez, Joaquin Ariño, Maria Platara, i M. Carme Espunya. A role for protein kinase CK2 in plant development: evidence obtained using a dominant-negative mutant.. Plant J 55 118–130
• 2008, Asier González, Joaquín Ariño, Josep A Biosca, i Carolina Larroy. Use of the TRP1 auxotrophic marker for gene disruption and phenotypic analysis in yeast: a note of warning.. FEMS Yeast Res 8 2–5