The laboratory was established in the early 90’s with the objective of studying the control of the glycogen metabolism by protein phosphatases in yeast. During the first half of the 90’s we identified and characterized a large number of Ser/Thr phosphatases from various sources (yeast, plants, etc.), such as Ppz1, Ppg1, various isoforms of PP1 and PPX. Moreover, we participated in the sequencing of the S. cerevisiae genome. Starting from the discovery of the role of the phosphatases Ppz in saline tolerance, we launched a research line that is still active. Since 2000, we also investigate the signaling mechanisms in response to the alkaline pH. The incorporation to the group of A. Casamayor in 2004 prompted the study of the roles of multiple isoforms of type 2C phosphatases in yeast and the various regulatory subunits of the type 1 phosphatase in S. cerevisiae. In the last few years we are investigating alkaline cation homeostasis in yeasts from systems Biology perspective.