Understanding COX-2 for the Design of New Cancer Drugs: Computational Study with Specific Photochromic Compounds Álex Pérez Sánchez Las ciclooxigenasas son una familia de enzimas esenciales en la regulación de la inflamación y otros procesos del cuerpo humano. Existen dos isoformas principales, COX-1 y COX-2, con distintos roles y patrones de expresión en los tejidos. […]
Theoretical Study of the Arachidonic Acid Conversion into Leukotriene A4 Catalyzed by Human 5-Lipoxygenase: Hydroperoxidation and Epoxidation Mechanisms and Arachidonic Acid Active Site Access Alejandro Cruz, Àngels González-Lafont, José M. Lluch Inflammation is at the base of many different diseases. Leukotrienes (LTs) are pro-inflammatory mediators derived from arachidonic acid (AA), which play significant roles in […]
Hoy, 20 de diciembre de 2023, Miquel Canyelles Niño ha defendido su tesis doctoral titulada: Theoretical and experimental study of the reaction mechanism of several lipoxygenases and hydrolases: governing their product pattern by mutagenesis.
Three-Photon Infrared Stimulation of Endogenous Neuroreceptors in Vivo Rosalba Sortino, Marina Cunquero, Gustavo Castro-Olvera, Ricard Gelabert, Miquel Moreno, Fabio Riefolo, Carlo Matera, Noèlia Fernàndez-Castillo, Luca Agnetta, Michael Decker, José Maria Lluch, Jordi Hernando, Pablo Loza-Alvarez, Pau Gorostiza To interrogate neural circuits and crack their codes, in vivobrain activity imaging must be combined with spatiotemporally precise […]
Illuminating the Dark Side of COX-2: Insights from Computational Simulations and Fluorescent Probes in Cancer Research Álex Pérez Sánchez Las ciclooxigenasas son una familia de enzimas que desempeñan un papel fundamental en la regulación de la inflamación, el dolor y la fiebre en el cuerpo humano. Hay dos isoformas principales de ciclooxigenasas, COX-1 y COX-2, […]
Different Structures—Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H-indoles and 5-(4-Methoxyphenyl)-1H-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15? Zhuravlev, A.; Cruz, A.; Chen, X.; Aksenov, V.; Golovanov, A.; Lluch J. M.; Kuhn, H.; González-Lafont, À. Ivanov I. Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer […]
Exploring 14S-HpDHA binding modes and its negative allosteric modulation in hALOX12-catalyzed MaR1 biosynthesis Pedro Martínez Zaragoza La respuesta inflamatoria está presente en un gran número de enfermedades como defensa del cuerpo contra lesiones e infecciones. Generalmente consta de dos fases. En la primera se produce la biosíntesis de sustancias como leucotrienos y prostaglandinas. A continuación, […]
Functional Characterization of Mouse and Human Arachidonic Acid Lipoxygenase 15B (ALOX15B) Orthologs and of Their Mutants Exhibiting Humanized and Murinized Reaction Specificities Kakularam, K. R.; Canyelles-Niño, M.; Chen, X.; Lluch J. M.; González-Lafont, À. González-Lafont; Kuhn, H. The arachidonic acid lipoxygenase 15B (ALOX15B) orthologs of men and mice form different reaction products when arachidonic acid […]
Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and pigALOX15-mini-LOX Canyelles-Niño, M.; González-Lafont, À.; Lluch, J.M. Human lipoxygenase 12 (hALOX12) catalyzes the conversion of docosahexaenoic acid (DHA) into mainly 14S-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid (14S-H(p)DHA). This hydroperoxidation reaction is followed by an epoxidation and hydrolysis process that finally leads to maresin 1 (MaR1), a potent bioactive specialized pro-resolving mediator […]
La Química Teórica contra las enfermedades humanas inflamatorias Josep Maria Lluch López La inflamación aguda es un mecanismo de defensa del huésped muy importante contra la infección, la homeostasis alterada o la lesión, consistente en una fase de iniciación, seguida de una fase de resolución. Esta fase de resolución está regulada por una serie de […]