One 4-year PhD position (Formación de Personal Investigador, FPI) is available in theMolecular Biomedicine group (MolBioMed) at the Chemistry Department of theUniversitat Autònoma de Barcelona (UAB).The project PID2023-147140NB-I00 funded by the Spanish Ministry of Science,Innovation and Universities is entitled: Approaching cancer as an inflammation-based disease: Theoretical development of innovative ways to design newpharmacological and photo-pharmacological […]
One 4-year PhD position (Formación de Personal Investigador, FPI) is available in theMolecular Biomedicine group (MolBioMed) at the Chemistry Department of theUniversitat Autònoma de Barcelona (UAB). The project PID2023-147140NB-I00 funded by the Spanish Ministry of Science,Innovation and Universities is entitled: Approaching cancer as an inflammation-based disease: Theoretical development of innovative ways to design newpharmacological and […]
Understanding COX-2 for the Design of New Cancer Drugs: Computational Study with Specific Photochromic Compounds Álex Pérez Sánchez Cyclooxygenases are a family of enzymes essential in the regulation of inflammation and other processes in the human body. There are two main isoforms, COX-1 and COX-2, with different roles and patterns of expression in tissues COX-1 […]
Theoretical Study of the Arachidonic Acid Conversion into Leukotriene A4 Catalyzed by Human 5-Lipoxygenase: Hydroperoxidation and Epoxidation Mechanisms and Arachidonic Acid Active Site Access Alejandro Cruz, Àngels González-Lafont, José M. Lluch Inflammation is at the base of many different diseases. Leukotrienes (LTs) are pro-inflammatory mediators derived from arachidonic acid (AA), which play significant roles in […]
Today, December 20, 2023, Miquel Canyelles Niño defended his doctoral thesis entitled: Theoretical and experimental study of the reaction mechanism of several lipoxygenases and hydrolases: governing their product pattern by mutagenesis.
Three-Photon Infrared Stimulation of Endogenous Neuroreceptors in Vivo Rosalba Sortino, Marina Cunquero, Gustavo Castro-Olvera, Ricard Gelabert, Miquel Moreno, Fabio Riefolo, Carlo Matera, Noèlia Fernàndez-Castillo, Luca Agnetta, Michael Decker, José Maria Lluch, Jordi Hernando, Pablo Loza-Alvarez, Pau Gorostiza To interrogate neural circuits and crack their codes, in vivobrain activity imaging must be combined with spatiotemporally precise […]
Illuminating the Dark Side of COX-2: Insights from Computational Simulations and Fluorescent Probes in Cancer Research Álex Pérez Sánchez Cyclooxygenases are a family of enzymes that play a critical role in regulating inflammation, pain, and fever in the human body. There are two main isoforms of cyclooxygenases, COX-1 and COX- 2, with different roles and […]
Different Structures—Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H-indoles and 5-(4-Methoxyphenyl)-1H-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15? Zhuravlev, A.; Cruz, A.; Chen, X.; Aksenov, V.; Golovanov, A.; Lluch J. M.; Kuhn, H.; González-Lafont, À. Ivanov I. Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer […]
Exploring 14S-HpDHA binding modes and its negative allosteric modulation in hALOX12-catalyzed MaR1 biosynthesis Pedro Martínez Zaragoza The inflammatory response is present in many diseases as the body’s defense against injuries and infections. Generally, it consists of two phases. In the first phase, the biosynthesis of substances such as leukotrienes and prostaglandins takes place. Subsequently, the […]
Functional Characterization of Mouse and Human Arachidonic Acid Lipoxygenase 15B (ALOX15B) Orthologs and of Their Mutants Exhibiting Humanized and Murinized Reaction Specificities Kakularam, K. R.; Canyelles-Niño, M.; Chen, X.; Lluch J. M.; González-Lafont, À. González-Lafont; Kuhn, H. The arachidonic acid lipoxygenase 15B (ALOX15B) orthologs of men and mice form different reaction products when arachidonic acid […]