One 4-year PhD position (Formación de Personal Investigador, FPI) is available in theMolecular Biomedicine group (MolBioMed) at the Chemistry Department of theUniversitat Autònoma de Barcelona (UAB). The project PID2023-147140NB-I00 funded by the Spanish Ministry of Science,Innovation and Universities is entitled: Approaching cancer as an inflammation-based disease: Theoretical development of innovative ways to design newpharmacological and […]
Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and pigALOX15-mini-LOX Canyelles-Niño, M.; González-Lafont, À.; Lluch, J.M. Human lipoxygenase 12 (hALOX12) catalyzes the conversion of docosahexaenoic acid (DHA) into mainly 14S-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid (14S-H(p)DHA). This hydroperoxidation reaction is followed by an epoxidation and hydrolysis process that finally leads to maresin 1 (MaR1), a potent bioactive specialized pro-resolving mediator […]
Understanding how reticulocyte 15-lipoxygenase-1 catalyzes the production of lipoxins in the 5(S),15(S)-DiHpETE biosynthetic pathway Àngels González Lafont Local acute inflammation of living organisms is a defense mechanism in response to tissue injury or against invasion by microbial pathogens. If it gets out of control, it becomes chronic and can lead to a wide range of […]