Hi ha disponible una plaça de doctorat de 4 anys (Formación de Personal Investigador, FPI) al grup de Biomedicina Molecular (MolBioMed) del Departament de Química de la Universitat Autònoma de Barcelona (UAB). El projecte PID2023-147140NB-I00 finançat pel Ministeri de Ciència, Innovació i Universitats espanyol es titula: Aproximació al càncer com a malaltia basada en la […]
Understanding COX-2 for the Design of New Cancer Drugs: Computational Study with Specific Photochromic Compounds Álex Pérez Sánchez Les ciclooxigenases són una família d’enzims essencials en la regulació de la inflamació i altres processos del cos humà. Hi ha dues isoformes principals, COX-1 i COX-2, amb diferents rols i patrons d’expressió als teixits. La COX-1 […]
Theoretical Study of the Arachidonic Acid Conversion into Leukotriene A4 Catalyzed by Human 5-Lipoxygenase: Hydroperoxidation and Epoxidation Mechanisms and Arachidonic Acid Active Site Access Alejandro Cruz, Àngels González-Lafont, José M. Lluch Inflammation is at the base of many different diseases. Leukotrienes (LTs) are pro-inflammatory mediators derived from arachidonic acid (AA), which play significant roles in acute […]
Avui, 20 de desembre del 2023, Miquel Canyelles Niño ha defensat la seva tesi doctoral titulada: Theoretical and experimental study of the reaction mechanism of several lipoxygenases and hydrolases: governing their product pattern by mutagenesis.
Three-Photon Infrared Stimulation of Endogenous Neuroreceptors in Vivo Rosalba Sortino, Marina Cunquero, Gustavo Castro-Olvera, Ricard Gelabert, Miquel Moreno, Fabio Riefolo, Carlo Matera, Noèlia Fernàndez-Castillo, Luca Agnetta, Michael Decker, José Maria Lluch, Jordi Hernando, Pablo Loza-Alvarez, Pau Gorostiza To interrogate neural circuits and crack their codes, in vivobrain activity imaging must be combined with spatiotemporally precise stimulation in three dimensions using genetic or pharmacological specificity. This challenge requires deep […]
Illuminating the Dark Side of COX-2: Insights from Computational Simulations and Fluorescent Probes in Cancer Research Álex Pérez Sánchez Les ciclooxigenases són una família d’enzims que tenen un paper fonamental en la regulació de la inflamació, el dolor i la febre. en el cos humà. Hi ha dues isoformes principals de ciclooxigenases, COX-1 i COX-2, […]
Different Structures—Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H-indoles and 5-(4-Methoxyphenyl)-1H-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15? Zhuravlev, A.; Cruz, A.; Chen, X.; Aksenov, V.; Golovanov, A.; Lluch J. M.; Kuhn, H.; González-Lafont, À. Ivanov I. Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer […]
Exploring 14S-HpDHA binding modes and its negative allosteric modulation in hALOX12-catalyzed MaR1 biosynthesis Pedro Martínez Zaragoza La resposta inflamatòria està present en un gran nombre de malalties com a defensa del cos contra lesions i infeccions. Generalment, consta de dues fases. En la primera, es produeix la biosíntesi de substàncies com leucotriens i prostaglandines. Seguidament, […]
Functional Characterization of Mouse and Human Arachidonic Acid Lipoxygenase 15B (ALOX15B) Orthologs and of Their Mutants Exhibiting Humanized and Murinized Reaction Specificities Kakularam, K. R.; Canyelles-Niño, M.; Chen, X.; Lluch J. M.; González-Lafont, À. González-Lafont; Kuhn, H. The arachidonic acid lipoxygenase 15B (ALOX15B) orthologs of men and mice form different reaction products when arachidonic acid […]
Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and pigALOX15-mini-LOX Canyelles-Niño, M.; González-Lafont, À.; Lluch, J.M. Human lipoxygenase 12 (hALOX12) catalyzes the conversion of docosahexaenoic acid (DHA) into mainly 14S-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid (14S-H(p)DHA). This hydroperoxidation reaction is followed by an epoxidation and hydrolysis process that finally leads to maresin 1 (MaR1), a potent bioactive specialized pro-resolving mediator (SPM) […]