Theoretical Study of the Arachidonic Acid Conversion into Leukotriene A4 Catalyzed by Human 5-Lipoxygenase: Hydroperoxidation and Epoxidation Mechanisms and Arachidonic Acid Active Site Access Alejandro Cruz, Àngels González-Lafont, José M. Lluch Inflammation is at the base of many different diseases. Leukotrienes (LTs) are pro-inflammatory mediators derived from arachidonic acid (AA), which play significant roles in […]
Different Structures—Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H-indoles and 5-(4-Methoxyphenyl)-1H-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15? Zhuravlev, A.; Cruz, A.; Chen, X.; Aksenov, V.; Golovanov, A.; Lluch J. M.; Kuhn, H.; González-Lafont, À. Ivanov I. Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer […]
Exploring 14S-HpDHA binding modes and its negative allosteric modulation in hALOX12-catalyzed MaR1 biosynthesis Pedro Martínez Zaragoza The inflammatory response is present in many diseases as the body’s defense against injuries and infections. Generally, it consists of two phases. In the first phase, the biosynthesis of substances such as leukotrienes and prostaglandins takes place. Subsequently, the […]
Functional Characterization of Mouse and Human Arachidonic Acid Lipoxygenase 15B (ALOX15B) Orthologs and of Their Mutants Exhibiting Humanized and Murinized Reaction Specificities Kakularam, K. R.; Canyelles-Niño, M.; Chen, X.; Lluch J. M.; González-Lafont, À. González-Lafont; Kuhn, H. The arachidonic acid lipoxygenase 15B (ALOX15B) orthologs of men and mice form different reaction products when arachidonic acid […]
Study of the conversion of leukotriene A4 to leukotriene B4 driven by leukotriene A4 hydrolase Miquel Canyelles Niño LTA4H is a bifunctional zinc metalloenzyme that converts leukotriene A4 (LTA4) into leukotriene B4 (LTB4), one of the most potent chemotactic agents involved in acute and chronic inflammatory diseases. In this reaction, LTA4H acts as an epoxide […]