Understanding COX-2 for the Design of New Cancer Drugs: Computational Study with Specific Photochromic Compounds Álex Pérez Sánchez Les ciclooxigenases són una família d’enzims essencials en la regulació de la inflamació i altres processos del cos humà. Hi ha dues isoformes principals, COX-1 i COX-2, amb diferents rols i patrons d’expressió als teixits. La COX-1 […]
Theoretical Study of the Arachidonic Acid Conversion into Leukotriene A4 Catalyzed by Human 5-Lipoxygenase: Hydroperoxidation and Epoxidation Mechanisms and Arachidonic Acid Active Site Access Alejandro Cruz, Àngels González-Lafont, José M. Lluch Inflammation is at the base of many different diseases. Leukotrienes (LTs) are pro-inflammatory mediators derived from arachidonic acid (AA), which play significant roles in acute […]
Illuminating the Dark Side of COX-2: Insights from Computational Simulations and Fluorescent Probes in Cancer Research Álex Pérez Sánchez Les ciclooxigenases són una família d’enzims que tenen un paper fonamental en la regulació de la inflamació, el dolor i la febre. en el cos humà. Hi ha dues isoformes principals de ciclooxigenases, COX-1 i COX-2, […]
Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and pigALOX15-mini-LOX Canyelles-Niño, M.; González-Lafont, À.; Lluch, J.M. Human lipoxygenase 12 (hALOX12) catalyzes the conversion of docosahexaenoic acid (DHA) into mainly 14S-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid (14S-H(p)DHA). This hydroperoxidation reaction is followed by an epoxidation and hydrolysis process that finally leads to maresin 1 (MaR1), a potent bioactive specialized pro-resolving mediator (SPM) […]