Theoretical Study of the Arachidonic Acid Conversion into Leukotriene A4 Catalyzed by Human 5-Lipoxygenase: Hydroperoxidation and Epoxidation Mechanisms and Arachidonic Acid Active Site Access Alejandro Cruz, Àngels González-Lafont, José M. Lluch Inflammation is at the base of many different diseases. Leukotrienes (LTs) are pro-inflammatory mediators derived from arachidonic acid (AA), which play significant roles in […]
Illuminating the Dark Side of COX-2: Insights from Computational Simulations and Fluorescent Probes in Cancer Research Álex Pérez Sánchez Cyclooxygenases are a family of enzymes that play a critical role in regulating inflammation, pain, and fever in the human body. There are two main isoforms of cyclooxygenases, COX-1 and COX- 2, with different roles and […]
Different Structures—Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H-indoles and 5-(4-Methoxyphenyl)-1H-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15? Zhuravlev, A.; Cruz, A.; Chen, X.; Aksenov, V.; Golovanov, A.; Lluch J. M.; Kuhn, H.; González-Lafont, À. Ivanov I. Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer […]
Exploring 14S-HpDHA binding modes and its negative allosteric modulation in hALOX12-catalyzed MaR1 biosynthesis Pedro Martínez Zaragoza The inflammatory response is present in many diseases as the body’s defense against injuries and infections. Generally, it consists of two phases. In the first phase, the biosynthesis of substances such as leukotrienes and prostaglandins takes place. Subsequently, the […]
Functional Characterization of Mouse and Human Arachidonic Acid Lipoxygenase 15B (ALOX15B) Orthologs and of Their Mutants Exhibiting Humanized and Murinized Reaction Specificities Kakularam, K. R.; Canyelles-Niño, M.; Chen, X.; Lluch J. M.; González-Lafont, À. González-Lafont; Kuhn, H. The arachidonic acid lipoxygenase 15B (ALOX15B) orthologs of men and mice form different reaction products when arachidonic acid […]